| Literature DB >> 18980322 |
Wei Wei1, Guang-Hui Ma, Gang Hu, Di Yu, Tom McLeish, Zhi-Guo Su, Zhe-Yu Shen.
Abstract
One-pot approach to couple the crystallization of CaCO(3) nanoparticles and the in situ symmetry-breaking assembly of these crystallites into hollow spherical shells was developed under the templating effect of a soluble starch. Further functional study using HP-a as an anticancer drug carrier (DOX) demonstrated its advantages for localizing drug release by the pH value-sensitive structure and enhancing cytotoxicity by increasing cellular uptake, perinuclear accumulation, and nuclear entry.Entities:
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Year: 2008 PMID: 18980322 DOI: 10.1021/ja8039585
Source DB: PubMed Journal: J Am Chem Soc ISSN: 0002-7863 Impact factor: 15.419