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Literature DB >> 18980164

IspH protein of the deoxyxylulose phosphate pathway: mechanistic studies with C1-deuterium-labeled substrate and fluorinated analogue.

Youli Xiao¹, Pinghua Liu.

Abstract

Entities: Chemical

Mesh：

Substances：

Year: 2008 PMID： 18980164 DOI： 10.1002/anie.200803452

Source DB: PubMed Journal: Angew Chem Int Ed Engl ISSN： 1433-7851 Impact factor: 15.336

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11 in total

1. Substrate analog studies of the ω-regiospecificity of Mycobacterium tuberculosis cholesterol metabolizing cytochrome P450 enzymes CYP124A1, CYP125A1 and CYP142A1.

Authors: Jonathan B Johnston; Arti A Singh; Anaelle A Clary; Chiung-Kuan Chen; Patricia Y Hayes; Sharon Chow; James J De Voss; Paul R Ortiz de Montellano
Journal: Bioorg Med Chem Date: 2012-05-11 Impact factor: 3.641

2. Bioorganometallic mechanism of action, and inhibition, of IspH.

Authors: Weixue Wang; Ke Wang; Yi-Liang Liu; Joo-Hwan No; Jikun Li; Mark J Nilges; Eric Oldfield
Journal: Proc Natl Acad Sci U S A Date: 2010-02-19 Impact factor: 11.205

3. Study of IspH, a key enzyme in the methylerythritol phosphate pathway using fluoro-substituted substrate analogues.

Authors: Youli Xiao; Wei-chen Chang; Hung-wen Liu; Pinghua Liu
Journal: Org Lett Date: 2011-10-07 Impact factor: 6.005

Review 4. Methylerythritol phosphate pathway of isoprenoid biosynthesis.

Authors: Lishan Zhao; Wei-chen Chang; Youli Xiao; Hung-wen Liu; Pinghua Liu
Journal: Annu Rev Biochem Date: 2013 Impact factor: 23.643

5. Mechanistic studies of an IspH-catalyzed reaction: implications for substrate binding and protonation in the biosynthesis of isoprenoids.

Authors: Wei-chen Chang; Youli Xiao; Hung-wen Liu; Pinghua Liu
Journal: Angew Chem Int Ed Engl Date: 2011-10-24 Impact factor: 15.336

10. Use of Broken-Symmetry Density Functional Theory To Characterize the IspH Oxidized State: Implications for IspH Mechanism and Inhibition.

Authors: Patrick G Blachly; Gregory M Sandala; Debra Ann Giammona; Tiqing Liu; Donald Bashford; J Andrew McCammon; Louis Noodleman
Journal: J Chem Theory Comput Date: 2014-08-13 Impact factor: 6.006

IspH protein of the deoxyxylulose phosphate pathway: mechanistic studies with C1-deuterium-labeled substrate and fluorinated analogue.

1. Substrate analog studies of the ω-regiospecificity of Mycobacterium tuberculosis cholesterol metabolizing cytochrome P450 enzymes CYP124A1, CYP125A1 and CYP142A1.

2. Bioorganometallic mechanism of action, and inhibition, of IspH.

3. Study of IspH, a key enzyme in the methylerythritol phosphate pathway using fluoro-substituted substrate analogues.

Review 4. Methylerythritol phosphate pathway of isoprenoid biosynthesis.

5. Mechanistic studies of an IspH-catalyzed reaction: implications for substrate binding and protonation in the biosynthesis of isoprenoids.

6. Probing the reaction mechanism of IspH protein by x-ray structure analysis.

7. Broken-Symmetry DFT Computations for the Reaction Pathway of IspH, an Iron-Sulfur Enzyme in Pathogenic Bacteria.

8. Utilizing a dynamical description of IspH to aid in the development of novel antimicrobial drugs.

9. Insights into the binding of pyridines to the iron-sulfur enzyme IspH.

10. Use of Broken-Symmetry Density Functional Theory To Characterize the IspH Oxidized State: Implications for IspH Mechanism and Inhibition.