Literature DB >> 1897954

Alpha-tocopherol (vitamin E) regulates vascular smooth muscle cell proliferation and protein kinase C activity.

D Boscoboinik1, A Szewczyk, A Azzi.   

Abstract

Alpha-Tocopherol (vitamin E) protects against free radical damage, which has been implicated in aging, cancer initiation, and atherosclerosis. We have found that physiological concentrations of alpha-tocopherol specifically inhibited aorta smooth muscle cell (VSMC, line A7r5) proliferation and protein kinase C (PKC) activity. Other water and lipid soluble antioxidants were inactive. alpha-Tocopherol inhibition of PKC and of VSMC proliferation may represent a physiological mechanism, relevant to the onset of diseased states such as atherosclerosis.

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Year:  1991        PMID： 1897954     DOI： 10.1016/0003-9861(91)90039-l

Source DB:  PubMed          Journal:  Arch Biochem Biophys        ISSN： 0003-9861            Impact factor:   4.013


  20 in total

1.  Vitamin E reduces cholesterol esterification and uptake of acetylated low density lipoprotein in macrophages.

Authors:  H Shige; T Ishikawa; M Suzukawa; M Nishiwaki; T Yamashita; K Nakajima; T Ito; K Higashi; M Ayaori; A Yonemura; P Nestel; H Nakamura
Journal:  Lipids       Date:  1998-12       Impact factor: 1.880

2.  Delivery of orally supplemented alpha-tocotrienol to vital organs of rats and tocopherol-transport protein deficient mice.

Authors:  Savita Khanna; Viren Patel; Cameron Rink; Sashwati Roy; Chandan K Sen
Journal:  Free Radic Biol Med       Date:  2005-11-15       Impact factor: 7.376

Review 3.  Oxidants, antioxidants, and the degenerative diseases of aging.

Authors:  B N Ames; M K Shigenaga; T M Hagen
Journal:  Proc Natl Acad Sci U S A       Date:  1993-09-01       Impact factor: 11.205

4.  Combined treatment of ascorbic acid or alpha-tocopherol with dopamine receptor antagonist or nitric oxide synthase inhibitor potentiates cataleptic effect in mice.

Authors:  M Lazzarini; C Salum; E A Del Bel
Journal:  Psychopharmacology (Berl)       Date:  2005-10-15       Impact factor: 4.530

5.  Inhibitory effects of RRR-alpha-tocopheryl succinate on benzo(a)pyrene (B(a)P)-induced forestomach carcinogenesis in female mice.

Authors:  K Wu; Y J Shan; Y Zhao; J W Yu; B H Liu
Journal:  World J Gastroenterol       Date:  2001-02       Impact factor: 5.742

6.  Alpha-Tocopherol Transfer Protein (alpha-TTP): Insights from Alpha-Tocopherol Transfer Protein Knockout Mice.

Authors:  Yunsook Lim; Maret G Traber
Journal:  Nutr Res Pract       Date:  2007-12-31       Impact factor: 1.926

7.  Nuclear factor-kappa B, p38, and stress-activated protein kinase mitogen-activated protein kinase signaling pathways regulate proinflammatory cytokines and apoptosis in human placental explants in response to oxidative stress: effects of antioxidant vitamins.

Authors:  Tereza Cindrova-Davies; Olivera Spasic-Boskovic; Eric Jauniaux; D Stephen Charnock-Jones; Graham J Burton
Journal:  Am J Pathol       Date:  2007-05       Impact factor: 4.307

8.  Influence of n-3 fatty acids on the growth of human breast cancer cells in vitro: relationship to peroxides and vitamin-E.

Authors:  V Chajès; W Sattler; A Stranzl; G M Kostner
Journal:  Breast Cancer Res Treat       Date:  1995-06       Impact factor: 4.872

9.  Role of the p50 subunit of NF-kappaB in vitamin E-induced changes in mice treated with the peroxisome proliferator, ciprofibrate.

Authors:  Karen G Calfee-Mason; Eun Y Lee; Brett T Spear; Howard P Glauert
Journal:  Food Chem Toxicol       Date:  2008-02-05       Impact factor: 6.023

10.  Early vitamin E supplementation attenuates diabetes-associated vascular dysfunction and the rise in protein kinase C-beta in mesenteric artery and ameliorates wall stiffness in femoral artery of Wistar rats.

Authors:  S J Wigg; M Tare; J Forbes; M E Cooper; M C Thomas; H A Coleman; H C Parkington; R C O'Brien
Journal:  Diabetologia       Date:  2004-06-08       Impact factor: 10.122
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