| Literature DB >> 18978778 |
Thorsten Kienast1, Ahmad R Hariri, Florian Schlagenhauf, Jana Wrase, Philipp Sterzer, Hans Georg Buchholz, Michael N Smolka, Gerhard Gründer, Paul Cumming, Yoshitaka Kumakura, Peter Bartenstein, Raymond J Dolan, Andreas Heinz.
Abstract
Dopamine is released under stress and modulates processing of aversive stimuli. We found that dopamine storage capacity in human amygdala, measured with 6-[(18)F]fluoro-L-DOPA positron emission tomography, was positively correlated with functional magnetic resonance imaging blood oxygen level-dependent signal changes in amygdala and dorsal anterior cingulate cortex that were evoked by aversive stimuli. Furthermore, functional connectivity between these two regions was inversely related to trait anxiety. Our results suggest that individual dopamine storage capacity in amygdala subserves modulation of emotional processing in amygdala and dorsal cingulate, thereby contributing to individual differences in anxious temperament.Entities:
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Year: 2008 PMID： 18978778 DOI： 10.1038/nn.2222
Source DB: PubMed Journal: Nat Neurosci ISSN： 1097-6256 Impact factor: 24.884