OBJECTIVES: Oral cancer is a worldwide phenomenon. It is thought to develop in a number of premalignant lesions. Protooncogene c fos is a known transformer of premalignant to malignant lesions. However, its role in oral carcinogenesis is not yet known. STUDY DESIGN: A total of 130 cases were studied comprising of premalignant lesions (n=50), squamous cell carcinoma (n=50) and controls (n=30). c fos expression was studied by immunohistochemistry. RESULTS: Premalignant lesions of oral cavity occurred at a lower age group (mean 39.2 years) compared to squamous cell carcinoma (mean 51.8 years), p <0.001. Mean c fos percentage positivity in squamous cell carcinomas (SCC), premalignant lesions and controls was 44.5+/-36.9%, 11.4+/-18.8% and 1.23+/-2.6% respectively, the differences were highly significant (p<0.001). c fos positivity also increased from mild (10.85+/-14.23%) to moderate dysplasia (19.64 +/-26.05%). CONCLUSIONS: The serially increasing c fos expression from normal mucosa to premalignant lesions to SCC and in dysplasias suggests that it could be an early gene to get activated and form transcription factor activator protein -1(AP-1).
OBJECTIVES:Oral cancer is a worldwide phenomenon. It is thought to develop in a number of premalignant lesions. Protooncogene c fos is a known transformer of premalignant to malignant lesions. However, its role in oral carcinogenesis is not yet known. STUDY DESIGN: A total of 130 cases were studied comprising of premalignant lesions (n=50), squamous cell carcinoma (n=50) and controls (n=30). c fos expression was studied by immunohistochemistry. RESULTS: Premalignant lesions of oral cavity occurred at a lower age group (mean 39.2 years) compared to squamous cell carcinoma (mean 51.8 years), p <0.001. Mean c fos percentage positivity in squamous cell carcinomas (SCC), premalignant lesions and controls was 44.5+/-36.9%, 11.4+/-18.8% and 1.23+/-2.6% respectively, the differences were highly significant (p<0.001). c fos positivity also increased from mild (10.85+/-14.23%) to moderate dysplasia (19.64 +/-26.05%). CONCLUSIONS: The serially increasing c fos expression from normal mucosa to premalignant lesions to SCC and in dysplasias suggests that it could be an early gene to get activated and form transcription factor activator protein -1(AP-1).
Authors: Eva M Briso; Juan Guinea-Viniegra; Latifa Bakiri; Zbigniew Rogon; Peter Petzelbauer; Roland Eils; Ronald Wolf; Mercedes Rincón; Peter Angel; Erwin F Wagner Journal: Genes Dev Date: 2013-09-12 Impact factor: 11.361
Authors: Konstanze B Bedal; Susanne Grässel; Peter J Oefner; Joerg Reinders; Torsten E Reichert; Richard Bauer Journal: PLoS One Date: 2014-01-23 Impact factor: 3.240