OBJECTIVE: Vitamin E and C given separately improve insulin sensitivity due to an inhibitory effect on oxidative stress and inflammation, however their combined effect on glucose control and inflammation is unknown. To investigate combined effect of Vitamin E and C in elderly with Impaired Fasting Glucose (IFG) on insulin action and substrate oxidation. DESIGN: Controlled-trial administration of Vitamin E (1000 mg/day) and Vitamin C (1000 UI/day) for four weeks. Hyperinsulinemic euglycemic glucose clamp was performed before and following supplementation. SETTING: Out-patient clinic. PARTICIPANTS: Thirteen older men with IFG. MAIN OUTCOME PARAMETERS: Variations in whole body glucose disposal (WBGD), anti-oxidant, and inflammatory cytokines plasma levels. RESULTS: An increase in plasma Vitamin E (8.3 + 0.8 vs. 64.9 + 2.1 micromol/l; p < 0.001] and C (35.9 + 5.4 vs. 79.4 + 7.4 micromol/l; p < 0.001) was found. Vitamin administration reduced insulin, glucose, lipid, TNF-alpha and [8-]isoprostane levels. Increase in plasma vitamin E levels correlated with decline in both plasma [8-]isoprostane levels (r = -0.58; p = 0.048) and TNF-alpha levels (r = - 0.62; p = 0.025), while no correlations were found for Vitamin C. Whole body glucose disposal (WBGD) (22.7 + 0.6 vs. 30.4 + 0.8 mmol x kg-1 x min-1; p = 0.001) and non-oxidative glucose metabolism rose after supplementation. Rise in plasma levels of Vitamin C and E correlated with WBGD. Multivariate linear regression models showed independent associations among the change in Vitamin E and the decline in TNF-alpha and [8-]isoprostane levels. CONCLUSIONS: Combined administration of Vitamin E and C lowered inflammation and improved insulin action through a rise in non-oxidative glucose metabolism.
OBJECTIVE:Vitamin E and C given separately improve insulin sensitivity due to an inhibitory effect on oxidative stress and inflammation, however their combined effect on glucose control and inflammation is unknown. To investigate combined effect of Vitamin E and C in elderly with Impaired Fasting Glucose (IFG) on insulin action and substrate oxidation. DESIGN: Controlled-trial administration of Vitamin E (1000 mg/day) and Vitamin C (1000 UI/day) for four weeks. Hyperinsulinemic euglycemic glucose clamp was performed before and following supplementation. SETTING: Out-patient clinic. PARTICIPANTS: Thirteen older men with IFG. MAIN OUTCOME PARAMETERS: Variations in whole body glucose disposal (WBGD), anti-oxidant, and inflammatory cytokines plasma levels. RESULTS: An increase in plasma Vitamin E (8.3 + 0.8 vs. 64.9 + 2.1 micromol/l; p < 0.001] and C (35.9 + 5.4 vs. 79.4 + 7.4 micromol/l; p < 0.001) was found. Vitamin administration reduced insulin, glucose, lipid, TNF-alpha and [8-]isoprostane levels. Increase in plasma vitamin E levels correlated with decline in both plasma [8-]isoprostane levels (r = -0.58; p = 0.048) and TNF-alpha levels (r = - 0.62; p = 0.025), while no correlations were found for Vitamin C. Whole body glucose disposal (WBGD) (22.7 + 0.6 vs. 30.4 + 0.8 mmol x kg-1 x min-1; p = 0.001) and non-oxidative glucose metabolism rose after supplementation. Rise in plasma levels of Vitamin C and E correlated with WBGD. Multivariate linear regression models showed independent associations among the change in Vitamin E and the decline in TNF-alpha and [8-]isoprostane levels. CONCLUSIONS: Combined administration of Vitamin E and C lowered inflammation and improved insulin action through a rise in non-oxidative glucose metabolism.
Authors: Sandra Pereira; Edward Park; Yusaku Mori; C Andrew Haber; Ping Han; Toyoyoshi Uchida; Laura Stavar; Andrei I Oprescu; Khajag Koulajian; Alexander Ivovic; Zhiwen Yu; Deling Li; Thomas A Bowman; Jay Dewald; Jamel El-Benna; David N Brindley; Roger Gutierrez-Juarez; Tony K T Lam; Sonia M Najjar; Robert A McKay; Sanjay Bhanot; I George Fantus; Adria Giacca Journal: Am J Physiol Endocrinol Metab Date: 2014-05-13 Impact factor: 4.310
Authors: Bibiana Garcia-Bailo; Ahmed El-Sohemy; Pierre S Haddad; Paul Arora; Firas Benzaied; Mohamed Karmali; Alaa Badawi Journal: Biologics Date: 2011-01-19
Authors: Fernanda Barros S Resende; Heleni Aires Clemente; Dalila Fernandes Bezerra; Evellyn Câmara Grilo; Larisse Rayanne M de Melo; Paula Emília N R Bellot; Raquel Costa S Dantas; Roberto Dimenstein Journal: Rev Paul Pediatr Date: 2014-06