BACKGROUND: The locations of cortex controlling motor, sensory, or language functions can change in adult humans under some circumstances, such as expanding tumours, trauma or continuous focal seizures. It is not clear what other circumstances might result in changes in cortical functional maps. METHODS: The results of extraoperative cortical mappings of motor, sensory, and language functions were compared in two epilepsy patients who underwent cortical resections on two separate occasions and who did not have brain tumours. RESULTS: It was found that the locations of motor functions could differ between the first and second procedures, but the locations of language functions were quite similar. The changes were not necessarily in or adjacent to epileptogenic regions or adjacent to resection boundaries. CONCLUSIONS: These findings support previous evidence indicating that cortical functional representations can change over time in humans, and suggest that these changes cannot be explained solely by lesion effects.
BACKGROUND: The locations of cortex controlling motor, sensory, or language functions can change in adult humans under some circumstances, such as expanding tumours, trauma or continuous focal seizures. It is not clear what other circumstances might result in changes in cortical functional maps. METHODS: The results of extraoperative cortical mappings of motor, sensory, and language functions were compared in two epilepsypatients who underwent cortical resections on two separate occasions and who did not have brain tumours. RESULTS: It was found that the locations of motor functions could differ between the first and second procedures, but the locations of language functions were quite similar. The changes were not necessarily in or adjacent to epileptogenic regions or adjacent to resection boundaries. CONCLUSIONS: These findings support previous evidence indicating that cortical functional representations can change over time in humans, and suggest that these changes cannot be explained solely by lesion effects.
Authors: Jean-Jacques Lemaire; Alexandra Golby; William M Wells; Sonia Pujol; Yanmei Tie; Laura Rigolo; Alexander Yarmarkovich; Steve Pieper; Carl-Fredrik Westin; Ferenc Jolesz; Ron Kikinis Journal: Brain Topogr Date: 2012-09-22 Impact factor: 3.020
Authors: Ronald B Willemse; Arjan Hillebrand; Hanneke E Ronner; W Peter Vandertop; Cornelis J Stam Journal: Neuroimage Clin Date: 2015-11-07 Impact factor: 4.881
Authors: Max Zimmermann; Karl Rössler; Martin Kaltenhäuser; Peter Grummich; Nadja Brandner; Michael Buchfelder; Arnd Dörfler; Konrad Kölble; Andreas Stadlbauer Journal: PLoS One Date: 2019-03-07 Impact factor: 3.240