Literature DB >> 18977324

Glycogen synthase kinase-3 and cancer: good cop, bad cop?

Satish Patel1, Jim Woodgett.   

Abstract

Dogma held that inhibition of the pleiotropic protein kinase glycogen synthase kinase-3 (GSK-3) was procarcinogenic due to its natural repression of beta-catenin. Now, Wang et al. have found the reverse in certain leukemias, possibly paving the way for small-molecule GSK-3 inhibitors as selective anticancer agents.

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Year:  2008        PMID： 18977324      PMCID： PMC3006450          DOI： 10.1016/j.ccr.2008.10.013

Source DB:  PubMed          Journal:  Cancer Cell        ISSN： 1535-6108            Impact factor:   31.743


  10 in total

Review 1.  GSK-3: tricks of the trade for a multi-tasking kinase.

Authors:  Bradley W Doble; James R Woodgett
Journal:  J Cell Sci       Date:  2003-04-01       Impact factor: 5.285

Review 2.  The many ways of Wnt in cancer.

Authors:  Paul Polakis
Journal:  Curr Opin Genet Dev       Date:  2007-02       Impact factor: 5.578

3.  Functional redundancy of GSK-3alpha and GSK-3beta in Wnt/beta-catenin signaling shown by using an allelic series of embryonic stem cell lines.

Authors:  Bradley W Doble; Satish Patel; Geoffrey A Wood; Lisa K Kockeritz; James R Woodgett
Journal:  Dev Cell       Date:  2007-06       Impact factor: 12.270

Review 4.  Preclinical efficacy on GSK-3 inhibitors: towards a future generation of powerful drugs.

Authors:  Ana Martinez
Journal:  Med Res Rev       Date:  2008-09       Impact factor: 12.944

5.  Glycogen synthase kinase 3 in MLL leukaemia maintenance and targeted therapy.

Authors:  Zhong Wang; Kevin S Smith; Mark Murphy; Obdulio Piloto; Tim C P Somervaille; Michael L Cleary
Journal:  Nature       Date:  2008-09-17       Impact factor: 49.962

6.  Role that phosphorylation of GSK3 plays in insulin and Wnt signalling defined by knockin analysis.

Authors:  Edward J McManus; Kei Sakamoto; Laura J Armit; Leah Ronaldson; Natalia Shpiro; Rodolfo Marquez; Dario R Alessi
Journal:  EMBO J       Date:  2005-03-24       Impact factor: 11.598

7.  Aberrant stabilization of c-Myc protein in some lymphoblastic leukemias.

Authors:  S Malempati; D Tibbitts; M Cunningham; Y Akkari; S Olson; G Fan; R C Sears
Journal:  Leukemia       Date:  2006-07-20       Impact factor: 11.528

8.  Aberrant nuclear accumulation of glycogen synthase kinase-3beta in human pancreatic cancer: association with kinase activity and tumor dedifferentiation.

Authors:  Andrei V Ougolkov; Martin E Fernandez-Zapico; Vladimir N Bilim; Thomas C Smyrk; Suresh T Chari; Daniel D Billadeau
Journal:  Clin Cancer Res       Date:  2006-09-01       Impact factor: 12.531

Review 9.  MLL translocations, histone modifications and leukaemia stem-cell development.

Authors:  Andrei V Krivtsov; Scott A Armstrong
Journal:  Nat Rev Cancer       Date:  2007-11       Impact factor: 60.716

Review 10.  The role of glycogen synthase kinase-3beta in normal haematopoiesis, angiogenesis and leukaemia.

Authors:  T Holmes; T A O'Brien; R Knight; R Lindeman; G Symonds; A Dolnikov
Journal:  Curr Med Chem       Date:  2008       Impact factor: 4.530
  10 in total
  44 in total

1.  Glycogen synthase kinase (GSK)-3 promotes p70 ribosomal protein S6 kinase (p70S6K) activity and cell proliferation.

Authors:  Sejeong Shin; Laura Wolgamott; Yonghao Yu; John Blenis; Sang-Oh Yoon
Journal:  Proc Natl Acad Sci U S A       Date:  2011-11-07       Impact factor: 11.205

Review 2.  GSK3beta: role in therapeutic landscape and development of modulators.

Authors:  S Phukan; V S Babu; A Kannoji; R Hariharan; V N Balaji
Journal:  Br J Pharmacol       Date:  2010-03-19       Impact factor: 8.739

Review 3.  Glycogen synthase kinase 3: a point of convergence for the host inflammatory response.

Authors:  Huizhi Wang; Jonathan Brown; Michael Martin
Journal:  Cytokine       Date:  2010-11-23       Impact factor: 3.861

4.  Impaired wound healing in hypoxic renal tubular cells: roles of hypoxia-inducible factor-1 and glycogen synthase kinase 3β/β-catenin signaling.

Authors:  Jianping Peng; Ganesan Ramesh; Lin Sun; Zheng Dong
Journal:  J Pharmacol Exp Ther       Date:  2011-10-18       Impact factor: 4.030

5.  Targeting of Lung Cancer Stem Cell Self-Renewal Pathway by a Small Molecule Verrucarin J.

Authors:  Karen Udoh; Seema Parte; Kelsey Carter; Aaron Mack; Sham S Kakar
Journal:  Stem Cell Rev Rep       Date:  2019-08       Impact factor: 5.739

Review 6.  Immunosenescence in monocytes, macrophages, and dendritic cells: lessons learned from the lung and heart.

Authors:  Phyllis-Jean Linton; Marilyn L Thoman
Journal:  Immunol Lett       Date:  2014-09-22       Impact factor: 3.685

7.  Exploiting an Asp-Glu "switch" in glycogen synthase kinase 3 to design paralog-selective inhibitors for use in acute myeloid leukemia.

Authors:  Florence F Wagner; Lina Benajiba; Arthur J Campbell; Michel Weïwer; Joshua R Sacher; Jennifer P Gale; Linda Ross; Alexandre Puissant; Gabriela Alexe; Amy Conway; Morgan Back; Yana Pikman; Ilene Galinsky; Daniel J DeAngelo; Richard M Stone; Taner Kaya; Xi Shi; Matthew B Robers; Thomas Machleidt; Jennifer Wilkinson; Olivier Hermine; Andrew Kung; Adam J Stein; Damodharan Lakshminarasimhan; Michael T Hemann; Edward Scolnick; Yan-Ling Zhang; Jen Q Pan; Kimberly Stegmaier; Edward B Holson
Journal:  Sci Transl Med       Date:  2018-03-07       Impact factor: 17.956

8.  Dynamic telomerase gene suppression via network effects of GSK3 inhibition.

Authors:  Alan E Bilsland; Stacey Hoare; Katrina Stevenson; Jane Plumb; Natividad Gomez-Roman; Claire Cairney; Sharon Burns; Kyle Lafferty-Whyte; Jon Roffey; Tim Hammonds; W Nicol Keith
Journal:  PLoS One       Date:  2009-07-31       Impact factor: 3.240

Review 9.  The PTEN-AKT3 signaling cascade as a therapeutic target in melanoma.

Authors:  Subbarao V Madhunapantula; Gavin P Robertson
Journal:  Pigment Cell Melanoma Res       Date:  2009-05-28       Impact factor: 4.693

10.  Inositol hexaphosphate suppresses growth and induces apoptosis in prostate carcinoma cells in culture and nude mouse xenograft: PI3K-Akt pathway as potential target.

Authors:  Mallikarjuna Gu; Srirupa Roy; Komal Raina; Chapla Agarwal; Rajesh Agarwal
Journal:  Cancer Res       Date:  2009-12-15       Impact factor: 12.701
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