| Literature DB >> 18977323 |
Daniel R Croft1, Michael F Olson.
Abstract
Switching between elongated and rounded modes of movement allows invasive tumor cells to adapt to varying microenvironments. In a recent issue of Cell, Sanz-Moreno et al. identify DOCK3, NEDD9, WAVE2, and ARHGAP22 as key molecules regulating Rac and Rho signaling that determine the mode of movement driving melanoma cell metastasis.Entities:
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Year: 2008 PMID: 18977323 DOI: 10.1016/j.ccr.2008.10.009
Source DB: PubMed Journal: Cancer Cell ISSN: 1535-6108 Impact factor: 31.743