| Literature DB >> 18977321 |
Bernd B Zeisig1, Ngai Cheung, Jenny Yeung, Chi Wai Eric So.
Abstract
The lack of a proper animal model has impeded understanding of the molecular mechanism of leukemia associated with the MLL-AF4 fusion. In this issue of Cancer Cell, Krivtsov et al. report a much-improved murine Mll-AF4 model and propose a molecular link with H3K79 methylation mediated by the histone methyltransferase DOT1L.Entities:
Mesh：
Substances：
Year: 2008 PMID： 18977321 DOI： 10.1016/j.ccr.2008.10.008
Source DB: PubMed Journal: Cancer Cell ISSN： 1535-6108 Impact factor: 31.743