Literature DB >> 18977175

Keeping it simple: an easy method for manipulating the expression levels of malaria proteins.

Tania F de Koning-Ward1, Paul R Gilson.   

Abstract

The ability to genetically manipulate malaria parasites in recent times has contributed considerably to our understanding of the biology of this deadly pathogen. Epp et al. have now expanded the repertoire of molecular tools available for the transgenesis system for the human malaria parasite Plasmodium falciparum by developing a simple methodology to regulate malaria gene expression. In this article, we comment on this technique and discuss its potential applications in the study of the biology of malaria parasites.

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Year:  2008        PMID： 18977175     DOI： 10.1016/j.pt.2008.09.009

Source DB:  PubMed          Journal:  Trends Parasitol        ISSN： 1471-4922


  5 in total

1.  Plasmodium falciparum inhibitor-3 homolog increases protein phosphatase type 1 activity and is essential for parasitic survival.

Authors:  Aline Fréville; Isabelle Landrieu; M Adelaida García-Gimeno; Jérôme Vicogne; Muriel Montbarbon; Benjamin Bertin; Alexis Verger; Hadidjatou Kalamou; Pascual Sanz; Elisabeth Werkmeister; Christine Pierrot; Jamal Khalife
Journal:  J Biol Chem       Date:  2011-11-28       Impact factor: 5.157

2.  Plasmodium falciparum dynein light chain 1 interacts with actin/myosin during blood stage development.

Authors:  Wassim Daher; Christine Pierrot; Hadidjatou Kalamou; Jennifer C Pinder; Gabriele Margos; Daniel Dive; Blandine Franke-Fayard; Chris J Janse; Jamal Khalife
Journal:  J Biol Chem       Date:  2010-04-26       Impact factor: 5.157

3.  Squalestatin is an inhibitor of carotenoid biosynthesis in Plasmodium falciparum.

Authors:  Heloisa B Gabriel; Marcia F Silva; Emília A Kimura; Gerhard Wunderlich; Alejandro M Katzin; Mauro F Azevedo
Journal:  Antimicrob Agents Chemother       Date:  2015-03-16       Impact factor: 5.191

4.  Systematic analysis of FKBP inducible degradation domain tagging strategies for the human malaria parasite Plasmodium falciparum.

Authors:  Mauro Ferreira de Azevedo; Paul R Gilson; Heloisa B Gabriel; Roseli F Simões; Fiona Angrisano; Jacob Baum; Brendan S Crabb; Gerhard Wunderlich
Journal:  PLoS One       Date:  2012-07-16       Impact factor: 3.240

5.  Cloning and characterization of bifunctional enzyme farnesyl diphosphate/geranylgeranyl diphosphate synthase from Plasmodium falciparum.

Authors:  Fabiana M Jordão; Heloisa B Gabriel; João M P Alves; Claudia B Angeli; Thaís D Bifano; Ardala Breda; Mauro F de Azevedo; Luiz A Basso; Gerhard Wunderlich; Emilia A Kimura; Alejandro M Katzin
Journal:  Malar J       Date:  2013-06-04       Impact factor: 2.979
  5 in total

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