| Literature DB >> 18976811 |
Adriana Morgan Oliveira1, Durvanei Augusto Maria, Martin Metzger, Camila Linardi, Ricardo Rodrigues Giorgi, Fernanda Moura, Gracia Aparecida Martinez, Sérgio Paulo Bydlowski, Estela Maria Novak.
Abstract
The chemokine stromal-derived factor-1alpha (SDF-1alpha) and its receptor CXCR4 are critically involved in directional migration and homing of plasma cells in multiple myeloma. Here, we show that the expression of SDF-1alpha and CXCR4 was significantly down-regulated in patients treated with thalidomide (n=10) as compared to newly diagnosed MM patients (n=31) and MM patients treated with other drugs (n=38). SDF-1 alpha and CXCR4 expression was also significantly decreased in a RPMI 8226 cell line treated with 10 and 20micromol/L of thalidomide. Our findings indicate that thalidomide therapy induces down-regulation of CXCR4 and its ligand SDF-1alpha in multiple myeloma.Entities:
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Year: 2008 PMID： 18976811 DOI： 10.1016/j.leukres.2008.09.018
Source DB: PubMed Journal: Leuk Res ISSN： 0145-2126 Impact factor: 3.156