Literature DB >> 18976654

Specific interaction of TFII-I with an upstream element on the HIV-1 LTR regulates induction of latent provirus.

Tom Malcolm1, Joanna Kam, Pouya Sadeghi Pour, Ivan Sadowski.   

Abstract

RBF-2 is a factor comprised of a USF1/2 heterodimer, whose association with a highly conserved upstream element (RBEIII) on the HIV-1 LTR requires a co-factor TFII-I. We have identified specific nucleotides, immediately 3' of RBEIII that are required for stable association of TFII-I with this region of the LTR. Mutations that inhibit interaction of TFII-I with DNA also prevent stimulation of USF binding to RBEIII, and render the integrated LTR unresponsive to T cell signaling. These results demonstrate an essential role of TFII-I bound at an upstream LTR element for viral replication.

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Year:  2008        PMID： 18976654     DOI： 10.1016/j.febslet.2008.10.032

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  12 in total

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2.  Identification and functional analysis of a second RBF-2 binding site within the HIV-1 promoter.

Authors:  Matthew S Dahabieh; Marcel Ooms; Tom Malcolm; Viviana Simon; Ivan Sadowski
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Authors:  Avery August
Journal:  Eur J Immunol       Date:  2009-09       Impact factor: 5.532

9.  An upstream YY1 binding site on the HIV-1 LTR contributes to latent infection.

Authors:  Wendy Bernhard; Kris Barreto; Sheetal Raithatha; Ivan Sadowski
Journal:  PLoS One       Date:  2013-10-08       Impact factor: 3.240

10.  ZASC1 stimulates HIV-1 transcription elongation by recruiting P-TEFb and TAT to the LTR promoter.

Authors:  James W Bruce; Rachel Reddington; Elizabeth Mathieu; Megan Bracken; John A T Young; Paul Ahlquist
Journal:  PLoS Pathog       Date:  2013-10-24       Impact factor: 6.823
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