OBJECT: The goal of this paper was to investigate the long-term outcome and the possible prognostic factors that might have influenced the persistence of posttraumatic epilepsy after penetrating head injuries sustained during the Iraq-Iran war (1980-1988). METHODS: In this retrospective study, the authors evaluated 189 patients who sustained penetrating head injury and suffered posttraumatic epilepsy during the Iraq-Iran war (mean 18.6 +/- 4.7 years after injury). The probabilities of persistent seizures (seizure occurrence in the past 2 years) in different periods after injury were estimated using the Kaplan-Meier method. The possible prognostic factors (patients and injury characteristics, clinical findings, and seizure characteristics) were studied using log-rank and Cox regression analysis. RESULTS: The probability of persistent seizures was 86.4% after 16 years and 74.7% after 21 years. In patients with < 3 pieces of shrapnel or no sphincter disturbances during seizure attacks, the probability of being seizure free after these 16 and 21 years was significantly higher. CONCLUSIONS: Early seizures, prophylactic antiepileptics drugs, and surgical intervention did not significantly affect long-term outcome in regard to persistence of seizures.
OBJECT: The goal of this paper was to investigate the long-term outcome and the possible prognostic factors that might have influenced the persistence of posttraumatic epilepsy after penetrating head injuries sustained during the Iraq-Iran war (1980-1988). METHODS: In this retrospective study, the authors evaluated 189 patients who sustained penetrating head injury and suffered posttraumatic epilepsy during the Iraq-Iran war (mean 18.6 +/- 4.7 years after injury). The probabilities of persistent seizures (seizure occurrence in the past 2 years) in different periods after injury were estimated using the Kaplan-Meier method. The possible prognostic factors (patients and injury characteristics, clinical findings, and seizure characteristics) were studied using log-rank and Cox regression analysis. RESULTS: The probability of persistent seizures was 86.4% after 16 years and 74.7% after 21 years. In patients with < 3 pieces of shrapnel or no sphincter disturbances during seizure attacks, the probability of being seizure free after these 16 and 21 years was significantly higher. CONCLUSIONS: Early seizures, prophylactic antiepileptics drugs, and surgical intervention did not significantly affect long-term outcome in regard to persistence of seizures.
Authors: Giulia Curia; Michael Levitt; Jason S Fender; John W Miller; Jeffrey Ojemann; Raimondo D'Ambrosio Journal: Cereb Cortex Date: 2010-11-26 Impact factor: 5.357
Authors: Raimondo D'Ambrosio; Clifford L Eastman; Felix Darvas; Jason S Fender; Derek R Verley; Federico M Farin; Hui-Wen Wilkerson; Nancy R Temkin; John W Miller; Jeffrey Ojemann; Steven M Rothman; Matthew D Smyth Journal: Ann Neurol Date: 2012-12-07 Impact factor: 10.422
Authors: Ali A Asadi-Pooya; Nahid Ashjazadeh; Ahmad Kamgarpour; Mousa Taghipour; Seyed Mohamad Rakei; Mohsen Farazdaghi; Soroor Inaloo; Mohammad Hadi Bagheri; Ali Razmkon; Zahra Zare Journal: Med J Islam Repub Iran Date: 2014-03-16