| Literature DB >> 18975957 |
Timothy D W Claridge1, Stephen G Davies, James A Lee, Rebecca L Nicholson, Paul M Roberts, Angela J Russell, Andrew D Smith, Steven M Toms.
Abstract
An experimentally simple protocol for the very highly (E)-selective Wadsworth-Emmons reaction [(E):(Z) selectivities in excess of 180:1 in some cases] of a range of straight-chain and branched aliphatic, substituted aromatic, and base-sensitive aldehydes via reaction with an alkyl diethylphosphonoacetate and MeMgBr is reported.Entities:
Year: 2008 PMID： 18975957 DOI： 10.1021/ol802212e
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005