Literature DB >> 18975896

A novel small molecule that alters shelterin integrity and triggers a DNA-damage response at telomeres.

Raphaël Rodriguez1, Sebastian Müller, Justin A Yeoman, Chantal Trentesaux, Jean-François Riou, Shankar Balasubramanian.   

Abstract

We describe a novel synthetic small molecule which shows an unprecedented stabilization of the human telomeric G-quadruplex with high selectivity relative to double-stranded DNA. We report that this compound can be used in vitro to inhibit telomerase activity and to uncap human POT1 (protection of telomeres 1) from the telomeric G-overhang. We also show that the small molecule G-quadruplex binder induces a partial alteration of shelterin through POT1 uncapping from telomeres in human HT1080 cancer cells and the presence of gammaH2AX foci colocalized at telomeres.

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Year:  2008        PMID： 18975896      PMCID： PMC2746963          DOI： 10.1021/ja805615w

Source DB:  PubMed          Journal:  J Am Chem Soc        ISSN： 0002-7863            Impact factor:   15.419


  27 in total

1.  A DNA damage checkpoint response in telomere-initiated senescence.

Authors:  Fabrizio d'Adda di Fagagna; Philip M Reaper; Lorena Clay-Farrace; Heike Fiegler; Philippa Carr; Thomas Von Zglinicki; Gabriele Saretzki; Nigel P Carter; Stephen P Jackson
Journal:  Nature       Date:  2003-11-05       Impact factor: 49.962

Review 2.  Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints.

Authors:  Aziz Sancar; Laura A Lindsey-Boltz; Keziban Unsal-Kaçmaz; Stuart Linn
Journal:  Annu Rev Biochem       Date:  2004       Impact factor: 23.643

3.  Telosome, a mammalian telomere-associated complex formed by multiple telomeric proteins.

Authors:  Dan Liu; Matthew S O'Connor; Jun Qin; Zhou Songyang
Journal:  J Biol Chem       Date:  2004-09-20       Impact factor: 5.157

4.  Inhibition of telomerase by G-quartet DNA structures.

Authors:  A M Zahler; J R Williamson; T R Cech; D M Prescott
Journal:  Nature       Date:  1991-04-25       Impact factor: 49.962

5.  The G-quadruplex ligand telomestatin inhibits POT1 binding to telomeric sequences in vitro and induces GFP-POT1 dissociation from telomeres in human cells.

Authors:  Dennis Gomez; Marie-Françoise O'Donohue; Thomas Wenner; Céline Douarre; Jérome Macadré; Pascale Koebel; Marie-Josèphe Giraud-Panis; Hervé Kaplan; Alain Kolkes; Kazuo Shin-ya; Jean-François Riou
Journal:  Cancer Res       Date:  2006-07-15       Impact factor: 12.701

6.  Inhibition of human telomerase by a G-quadruplex-interactive compound.

Authors:  D Sun; B Thompson; B E Cathers; M Salazar; S M Kerwin; J O Trent; T C Jenkins; S Neidle; L H Hurley
Journal:  J Med Chem       Date:  1997-07-04       Impact factor: 7.446

7.  Oxazole-based peptide macrocycles: a new class of G-quadruplex binding ligands.

Authors:  Katja Jantos; Raphaël Rodriguez; Sylvain Ladame; Pravin S Shirude; Shankar Balasubramanian
Journal:  J Am Chem Soc       Date:  2006-10-25       Impact factor: 15.419

8.  Tetramethylpyridiniumporphyrazines--a new class of G-quadruplex inducing and stabilising ligands.

Authors:  Diana P N Gonçalves; Raphaël Rodriguez; Shankar Balasubramanian; Jeremy K M Sanders
Journal:  Chem Commun (Camb)       Date:  2006-09-27       Impact factor: 6.222

Review 9.  Shelterin: the protein complex that shapes and safeguards human telomeres.

Authors:  Titia de Lange
Journal:  Genes Dev       Date:  2005-09-15       Impact factor: 12.890

10.  Preferential binding of a G-quadruplex ligand to human chromosome ends.

Authors:  Christine Granotier; Gaëlle Pennarun; Lydia Riou; Françoise Hoffschir; Laurent R Gauthier; Anne De Cian; Dennis Gomez; Eliane Mandine; Jean-François Riou; Jean-Louis Mergny; Patrick Mailliet; Bernard Dutrillaux; François D Boussin
Journal:  Nucleic Acids Res       Date:  2005-07-28       Impact factor: 16.971
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  120 in total

Review 1.  Unravelling the genomic targets of small molecules using high-throughput sequencing.

Authors:  Raphaël Rodriguez; Kyle M Miller
Journal:  Nat Rev Genet       Date:  2014-10-14       Impact factor: 53.242

2.  Specialization among iron-sulfur cluster helicases to resolve G-quadruplex DNA structures that threaten genomic stability.

Authors:  Sanjay Kumar Bharti; Joshua A Sommers; Fourbears George; Jochen Kuper; Florian Hamon; Kazuo Shin-ya; Marie-Paule Teulade-Fichou; Caroline Kisker; Robert M Brosh
Journal:  J Biol Chem       Date:  2013-08-09       Impact factor: 5.157

3.  ESI-MS Investigation of an Equilibrium between a Bimolecular Quadruplex DNA and a Duplex DNA/RNA Hybrid.

Authors:  Monica L Birrento; Tracy M Bryan; Siritron Samosorn; Jennifer L Beck
Journal:  J Am Soc Mass Spectrom       Date:  2015-04-24       Impact factor: 3.109

4.  G-quadruplexes significantly stimulate Pif1 helicase-catalyzed duplex DNA unwinding.

Authors:  Xiao-Lei Duan; Na-Nv Liu; Yan-Tao Yang; Hai-Hong Li; Ming Li; Shuo-Xing Dou; Xu-Guang Xi
Journal:  J Biol Chem       Date:  2015-01-27       Impact factor: 5.157

5.  G-quadruplex forming region within WT1 promoter is selectively targeted by daunorubicin and mitoxantrone: A possible mechanism for anti-leukemic effect of drugs.

Authors:  Saeedeh Ghazaey Zidanloo; Abasalt Hosseinzadeh Colagar; Hossein Ayatollahi; Zahra Bagheryan
Journal:  J Biosci       Date:  2019-03       Impact factor: 1.826

6.  Mechanism of the antiproliferative activity of some naphthalene diimide G-quadruplex ligands.

Authors:  Sonja M Hampel; Antonella Pepe; Karin M Greulich-Bode; Sanjay V Malhotra; Anthony P Reszka; Sebastian Veith; Petra Boukamp; Stephen Neidle
Journal:  Mol Pharmacol       Date:  2012-11-27       Impact factor: 4.436

7.  Quantitative visualization of DNA G-quadruplex structures in human cells.

Authors:  Giulia Biffi; David Tannahill; John McCafferty; Shankar Balasubramanian
Journal:  Nat Chem       Date:  2013-01-20       Impact factor: 24.427

8.  Cooperative Heteroligand Interaction with G-Quadruplexes Shows Evidence of Allosteric Binding.

Authors:  Shankar Pandey; Yuanyuan Li; Montwaun D Young; Shankar Mandal; Laichun Lu; Jacob T Shelley; Hanbin Mao
Journal:  Biochemistry       Date:  2020-09-03       Impact factor: 3.162

9.  G-quadruplex nucleic acids as therapeutic targets.

Authors:  Shankar Balasubramanian; Stephen Neidle
Journal:  Curr Opin Chem Biol       Date:  2009-06-08       Impact factor: 8.822

10.  The G-quadruplex ligand telomestatin impairs binding of topoisomerase IIIalpha to G-quadruplex-forming oligonucleotides and uncaps telomeres in ALT cells.

Authors:  Nassima Temime-Smaali; Lionel Guittat; Assitan Sidibe; Kazuo Shin-ya; Chantal Trentesaux; Jean-François Riou
Journal:  PLoS One       Date:  2009-09-09       Impact factor: 3.240
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