Literature DB >> 1897516

The effect of 1-hydroxyvitamin D3 for prolongation of leukemic transformation-free survival in myelodysplastic syndromes.

S Motomura1, H Kanamori, A Maruta, F Kodama, T Ohkubo.   

Abstract

Leukemic transformation (LT) free survival was studied in 30 patients with myelodysplastic syndromes (MDS). In 15 cases, 4-6 micrograms/day of 1-hydroxyvitamin D3 was administered, for a median duration of 17 months (D-group), other subjects had no therapy (N group). LT free survival of the D group had significant advantage over that of the N group according to the Kaplan-Meier method (P less than 0.001). In addition, 7 cases in the N group developed acute leukemia, in contrast to only one in the D group (P less than 0.05). These results suggest that oral administration of 1-hydroxyvitamin D3 prevents the progression of MDS to overt leukemia under the effect of differentiation capacity from blasts to monocytes.

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Year:  1991        PMID： 1897516     DOI： 10.1002/ajh.2830380112

Source DB:  PubMed          Journal:  Am J Hematol        ISSN： 0361-8609            Impact factor:   10.047


  9 in total

1.  19-nor-1alpha,25-dihydroxyvitamin D(2) (paricalcitol): effects on clonal proliferation, differentiation, and apoptosis in human leukemic cell lines.

Authors:  István Molnár; Timothy Kute; Mark C Willingham; Bayard L Powell; William H Dodge; Gary G Schwartz
Journal:  J Cancer Res Clin Oncol       Date:  2003-02-12       Impact factor: 4.553

Review 2.  Effect of Vitamin D on Graft-versus-Host Disease.

Authors:  Alfonso Rodríguez-Gil; Estrella Carrillo-Cruz; Cristina Marrero-Cepeda; Guillermo Rodríguez; José A Pérez-Simón
Journal:  Biomedicines       Date:  2022-04-24

3.  Phase II study of doxercalciferol for the treatment of myelodysplastic syndrome.

Authors:  Adam Petrich; Brad Kahl; Howard Bailey; Kyungmann Kim; Nancy Turman; Mark Juckett
Journal:  Leuk Lymphoma       Date:  2008-01

Review 4.  Vitamin D3-driven signals for myeloid cell differentiation--implications for differentiation therapy.

Authors:  Philip J Hughes; Ewa Marcinkowska; Elzbieta Gocek; George P Studzinski; Geoffrey Brown
Journal:  Leuk Res       Date:  2009-10-06       Impact factor: 3.156

Review 5.  Vitamin D Derivatives in Acute Myeloid Leukemia: The Matter of Selecting the Right Targets.

Authors:  Ewa Marcinkowska
Journal:  Nutrients       Date:  2022-07-12       Impact factor: 6.706

6.  Clinical experience using vitamin d and analogs in the treatment of myelodysplasia and acute myeloid leukemia: a review of the literature.

Authors:  Jonathan S Harrison; Alexander Bershadskiy
Journal:  Leuk Res Treatment       Date:  2012-07-30

Review 7.  The role of vitamin D in hematologic disease and stem cell transplantation.

Authors:  Aric C Hall; Mark B Juckett
Journal:  Nutrients       Date:  2013-06-18       Impact factor: 5.717

Review 8.  The future of vitamin D analogs.

Authors:  Carlien Leyssens; Lieve Verlinden; Annemieke Verstuyf
Journal:  Front Physiol       Date:  2014-04-03       Impact factor: 4.566

Review 9.  Vitamin D: Effect on Haematopoiesis and Immune System and Clinical Applications.

Authors:  Mayte Medrano; Estrella Carrillo-Cruz; Isabel Montero; Jose A Perez-Simon
Journal:  Int J Mol Sci       Date:  2018-09-08       Impact factor: 5.923
  9 in total

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