Literature DB >> 18974105

Conspirators in a capital crime: co-deletion of p18INK4c and p16INK4a/p14ARF/p15INK4b in glioblastoma multiforme.

David A Solomon1, Jung-Sik Kim, Walter Jean, Todd Waldman.   

Abstract

Glioblastoma multiforme (GBM) is one of the most dreaded cancer diagnoses due to its poor prognosis and the limited treatment options. Homozygous deletion of the p16(INK4a)/p14(ARF)/p15(INK4b) locus is among the most common genetic alterations in GBM. Two recent studies have shown that deletion and mutation of another INK4 family member, p18(INK4c), also drives the pathogenesis of GBM. This minireview will discuss the known roles for p18(INK4c) in the initiation and progression of cancer and suggest opportunities for future studies.

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Year:  2008        PMID： 18974105      PMCID： PMC2828676          DOI： 10.1158/0008-5472.CAN-08-2084

Source DB:  PubMed          Journal:  Cancer Res        ISSN： 0008-5472            Impact factor:   12.701


  31 in total

1.  Analysis of the p16INK4A, p15INK4B and p18INK4C genes in multiple myeloma.

Authors:  T Tasaka; J Berenson; R Vescio; T Hirama; C W Miller; M Nagai; J Takahara; H P Koeffler
Journal:  Br J Haematol       Date:  1997-01       Impact factor: 6.998

2.  Alterations of the tumor suppressor genes CDKN2A (p16(INK4a)), p14(ARF), CDKN2B (p15(INK4b)), and CDKN2C (p18(INK4c)) in atypical and anaplastic meningiomas.

Authors:  J Boström; B Meyer-Puttlitz; M Wolter; B Blaschke; R G Weber; P Lichter; K Ichimura; V P Collins; G Reifenberger
Journal:  Am J Pathol       Date:  2001-08       Impact factor: 4.307

3.  Homozygous deletions of the CDKN2C/p18INK4C gene on the short arm of chromosome 1 in anaplastic oligodendrogliomas.

Authors:  U Pohl; J G Cairncross; D N Louis
Journal:  Brain Pathol       Date:  1999-10       Impact factor: 6.508

4.  Identification of p18 INK4c as a tumor suppressor gene in glioblastoma multiforme.

Authors:  David A Solomon; Jung-Sik Kim; Sultan Jenkins; Habtom Ressom; Michael Huang; Nicholas Coppa; Lauren Mabanta; Darell Bigner; Hai Yan; Walter Jean; Todd Waldman
Journal:  Cancer Res       Date:  2008-04-01       Impact factor: 12.701

5.  A p18 mutant defective in CDK6 binding in human breast cancer cells.

Authors:  J Lapointe; Y Lachance; Y Labrie; C Labrie
Journal:  Cancer Res       Date:  1996-10-15       Impact factor: 12.701

6.  Regulation of the human cyclin-dependent kinase inhibitor p18INK4c by the transcription factors E2F1 and Sp1.

Authors:  Alexandre Blais; Didier Monté; Frédéric Pouliot; Claude Labrie
Journal:  J Biol Chem       Date:  2002-06-20       Impact factor: 5.157

Review 7.  Malignant astrocytic glioma: genetics, biology, and paths to treatment.

Authors:  Frank B Furnari; Tim Fenton; Robert M Bachoo; Akitake Mukasa; Jayne M Stommel; Alexander Stegh; William C Hahn; Keith L Ligon; David N Louis; Cameron Brennan; Lynda Chin; Ronald A DePinho; Webster K Cavenee
Journal:  Genes Dev       Date:  2007-11-01       Impact factor: 11.361

8.  CDKN2 (p16/MTS1) gene deletion or CDK4 amplification occurs in the majority of glioblastomas.

Authors:  E E Schmidt; K Ichimura; G Reifenberger; V P Collins
Journal:  Cancer Res       Date:  1994-12-15       Impact factor: 12.701

9.  Growth suppression by p18, a p16INK4/MTS1- and p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function.

Authors:  K L Guan; C W Jenkins; Y Li; M A Nichols; X Wu; C L O'Keefe; A G Matera; Y Xiong
Journal:  Genes Dev       Date:  1994-12-15       Impact factor: 11.361

10.  Paradoxical expression of INK4c in proliferative multiple myeloma tumors: bi-allelic deletion vs increased expression.

Authors:  Amel Dib; Timothy R Peterson; Laura Raducha-Grace; Adriana Zingone; Fenghuang Zhan; Ichiro Hanamura; Bart Barlogie; John Shaughnessy; W Michael Kuehl
Journal:  Cell Div       Date:  2006-10-18       Impact factor: 5.130
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  21 in total

1.  Sample type bias in the analysis of cancer genomes.

Authors:  David A Solomon; Jung-Sik Kim; Habtom W Ressom; Zita Sibenaller; Timothy Ryken; Walter Jean; Darell Bigner; Hai Yan; Todd Waldman
Journal:  Cancer Res       Date:  2009-06-30       Impact factor: 12.701

2.  The prognostic value of Ki-67, p53, epidermal growth factor receptor, 1p36, 9p21, 10q23, and 17p13 in skull base chordomas.

Authors:  Craig Horbinski; Gerard J Oakley; Kathleen Cieply; Geeta S Mantha; Marina N Nikiforova; Sanja Dacic; Raja R Seethala
Journal:  Arch Pathol Lab Med       Date:  2010-08       Impact factor: 5.534

Review 3.  Long non-coding PANDAR as a novel biomarker in human cancer: A systematic review.

Authors:  Yifan Zou; Yuantang Zhong; Junjie Wu; Huizhong Xiao; Xintao Zhang; Xinhui Liao; Jianfa Li; Xuhua Mao; Yuchen Liu; Fuyou Zhang
Journal:  Cell Prolif       Date:  2017-12-10       Impact factor: 6.831

4.  Contrasting behavior of the p18INK4c and p16INK4a tumor suppressors in both replicative and oncogene-induced senescence.

Authors:  Sladjana Gagrica; Sharon Brookes; Emma Anderton; Janice Rowe; Gordon Peters
Journal:  Cancer Res       Date:  2011-11-11       Impact factor: 12.701

Review 5.  Deregulated signaling pathways in glioblastoma multiforme: molecular mechanisms and therapeutic targets.

Authors:  Hua Mao; Drake G Lebrun; Jingxuan Yang; Vivian F Zhu; Min Li
Journal:  Cancer Invest       Date:  2012-01       Impact factor: 2.176

Review 6.  RNA processing as an alternative route to attack glioblastoma.

Authors:  Fabiana Marcelino Meliso; Christopher G Hubert; Pedro A Favoretto Galante; Luiz O Penalva
Journal:  Hum Genet       Date:  2017-06-12       Impact factor: 4.132

7.  Identification of valid endogenous control genes for determining gene expression in human glioma.

Authors:  Simone Kreth; Jens Heyn; Stefan Grau; Hans A Kretzschmar; Rupert Egensperger; Friedrich W Kreth
Journal:  Neuro Oncol       Date:  2010-02-05       Impact factor: 12.300

8.  Signatures of mutation and selection in the cancer genome.

Authors:  Graham R Bignell; Chris D Greenman; Helen Davies; Adam P Butler; Sarah Edkins; Jenny M Andrews; Gemma Buck; Lina Chen; David Beare; Calli Latimer; Sara Widaa; Jonathon Hinton; Ciara Fahey; Beiyuan Fu; Sajani Swamy; Gillian L Dalgliesh; Bin T Teh; Panos Deloukas; Fengtang Yang; Peter J Campbell; P Andrew Futreal; Michael R Stratton
Journal:  Nature       Date:  2010-02-18       Impact factor: 49.962

9.  Impact of meriolins, a new class of cyclin-dependent kinase inhibitors, on malignant glioma proliferation and neo-angiogenesis.

Authors:  Marie Jarry; Céline Lecointre; Céline Malleval; Laurence Desrues; Marie-Thérèse Schouft; Vadim Lejoncour; François Liger; Gildas Lyvinec; Benoît Joseph; Nadège Loaëc; Laurent Meijer; Jérôme Honnorat; Pierrick Gandolfo; Hélène Castel
Journal:  Neuro Oncol       Date:  2014-06-02       Impact factor: 12.300

10.  Amplification and overexpression of Hsa-miR-30b, Hsa-miR-30d and KHDRBS3 at 8q24.22-q24.23 in medulloblastoma.

Authors:  Yuan Lu; Sarra L Ryan; David J Elliott; Graham R Bignell; P Andrew Futreal; David W Ellison; Simon Bailey; Steven C Clifford
Journal:  PLoS One       Date:  2009-07-07       Impact factor: 3.240
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