OBJECTIVE: To analyze whether the administration of low-dose aspirin during IVF treatment improves the uterine blood flow and improves ongoing pregnancy rates for non-tubal factor IVF patients with previous failed conception. DESIGN: Prospective double-blind placebo-controlled trial. SETTING:University fertility clinic. PATIENT(S): Non-tubal IVF patients with previous failed conception. INTERVENTION(S): Daily 100 mg aspirin or placebo throughout an IVF treatment with a long GnRH-agonist stimulation protocol. MAIN OUTCOME MEASURE(S): Ongoing pregnancy rate, pulsatility index of the uterine artery. RESULT(S): Of 169 patients, 84 were assigned toaspirin treatment and 85 to placebo treatment. In the aspirin group, 28 patients (35.4%) had an ongoing pregnancy, and in the placebo group, 26 patients (31.0%) had an ongoing pregnancy. Multilevel analyses showed that the pulsatility index of the uterine artery was not affected by aspirin or placebo treatment. CONCLUSION(S): Low-dose aspirin administration during IVF treatment does not improve pregnancy rates of non-tubal factor IVF patients with previous failed conception, and it does not affect the arterial uterine blood flow.
RCT Entities:
OBJECTIVE: To analyze whether the administration of low-dose aspirin during IVF treatment improves the uterine blood flow and improves ongoing pregnancy rates for non-tubal factor IVFpatients with previous failed conception. DESIGN: Prospective double-blind placebo-controlled trial. SETTING: University fertility clinic. PATIENT(S): Non-tubal IVFpatients with previous failed conception. INTERVENTION(S): Daily 100 mg aspirin or placebo throughout an IVF treatment with a long GnRH-agonist stimulation protocol. MAIN OUTCOME MEASURE(S): Ongoing pregnancy rate, pulsatility index of the uterine artery. RESULT(S): Of 169 patients, 84 were assigned to aspirin treatment and 85 to placebo treatment. In the aspirin group, 28 patients (35.4%) had an ongoing pregnancy, and in the placebo group, 26 patients (31.0%) had an ongoing pregnancy. Multilevel analyses showed that the pulsatility index of the uterine artery was not affected by aspirin or placebo treatment. CONCLUSION(S): Low-dose aspirin administration during IVF treatment does not improve pregnancy rates of non-tubal factor IVFpatients with previous failed conception, and it does not affect the arterial uterine blood flow.
Authors: Kathryn A McInerney; Elizabeth E Hatch; Amelia K Wesselink; Kenneth J Rothman; Ellen M Mikkelsen; Lauren A Wise Journal: Hum Reprod Date: 2016-11-05 Impact factor: 6.918
Authors: Matthew T Connell; Lindsey A Sjaarda; Rose G Radin; Daniel Kuhr; Sunni L Mumford; Torie C Plowden; Robert M Silver; Enrique F Schisterman Journal: Semin Reprod Med Date: 2017-10-16 Impact factor: 1.303
Authors: Anne Marie Z Jukic; Ponnu Padiyara; Michael B Bracken; D Robert McConnaughey; Anne Z Steiner Journal: Am J Obstet Gynecol Date: 2019-11-15 Impact factor: 8.661