| Literature DB >> 1897377 |
L Tune1, J Brandt, J J Frost, G Harris, H Mayberg, C Steele, A Burns, J Sapp, M F Folstein, H N Wagner.
Abstract
The effect of acute, intravenous administration of physostigmine on measures of brain activity and cognitive functioning were investigated in 14 patients with Alzheimer's disease. Regional cerebral glucose metabolism was assessed using (18F)-fluoro-2-deoxy-D-glucose and positron emission tomography, and cerebral blood flow was assessed using 123I-iodoamphetamine single photon emission tomography. Although physostigmine enhanced cerebral blood flow in most patients, only one patient showed significant clinical improvement. This patient, however, also showed a very pronounced improvement in cerebral glucose metabolism. It is concluded that these preliminary findings hold considerable promise for our appreciation of the pathophysiology of dementing illness as well as our understanding of centrally acting compounds of interest in Alzheimer's disease.Entities:
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Year: 1991 PMID： 1897377 DOI： 10.1111/j.1600-0447.1991.tb03111.x
Source DB: PubMed Journal: Acta Psychiatr Scand Suppl ISSN： 0065-1591