Literature DB >> 1897244

Characterization of the principal metabolite of quinine in human urine by 1H-n.m.r. spectroscopy.

O O Bolaji1, C P Babalola, P A Dixon.   

Abstract

1. The major metabolite of quinine in human urine, which is also the sole metabolite in human plasma and saliva, has been identified and characterized by chemical ionization mass spectrometry and 1H-n.m.r. spectrometry. 2. The mass spectrum showed that an oxygen atom is incorporated in the quinuclidine nucleus, and the exact position of the oxidation was established from the n.m.r. spectrum to be at the C-3 position.

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Year:  1991        PMID: 1897244     DOI: 10.3109/00498259109039484

Source DB:  PubMed          Journal:  Xenobiotica        ISSN: 0049-8254            Impact factor:   1.908


  2 in total

1.  Disposition of quinine in rats with induced renal failure.

Authors:  C O Onyeji; P A Dixon; N C Ugwu
Journal:  Pharm Weekbl Sci       Date:  1992-08-21

2.  CYP450 phenotyping and metabolite identification of quinine by accurate mass UPLC-MS analysis: a possible metabolic link to blackwater fever.

Authors:  Sean R Marcsisin; Xiannu Jin; Theresa Bettger; Nicholas McCulley; Jason C Sousa; G Dennis Shanks; Babu L Tekwani; Rajnish Sahu; Gregory A Reichard; Richard J Sciotti; Victor Melendez; Brandon S Pybus
Journal:  Malar J       Date:  2013-06-21       Impact factor: 2.979

  2 in total

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