PURPOSE: To test whether inhalation of the phosphodiesterase 3 inhibitor milrinone may attenuate experimental acute lung injury (ALI). METHODS: In rats, ALI was induced by infusion of oleic acid (OA). After 30 min, milrinone was inhaled either as single dose, or repeatedly in 30 min intervals. In mice, ALI was induced by intratracheal instillation of hydrochloric acid, followed by a single milrinone inhalation. RESULTS: Four hours after OA infusion, ALI was evident as lung inflammation, protein-rich edema and hypoxemia. A single inhalation of milrinone attenuated the increase in lung wet-to-dry weight ratio and myeloperoxidase activity, and reduced protein concentration, neutrophil counts and TNF-alpha levels in bronchoalveolar lavage. This effect was further pronounced when milrinone was repeatedly inhaled. In mice with acid-induced ALI, milrinone attenuated hypoxemia and prevented the increase in lung myeloperoxidase activity. CONCLUSIONS: Inhalation of aerosolized milrinone may present a novel therapeutic strategy for the treatment of ALI.
PURPOSE: To test whether inhalation of the phosphodiesterase 3 inhibitor milrinone may attenuate experimental acute lung injury (ALI). METHODS: In rats, ALI was induced by infusion of oleic acid (OA). After 30 min, milrinone was inhaled either as single dose, or repeatedly in 30 min intervals. In mice, ALI was induced by intratracheal instillation of hydrochloric acid, followed by a single milrinone inhalation. RESULTS: Four hours after OA infusion, ALI was evident as lung inflammation, protein-rich edema and hypoxemia. A single inhalation of milrinone attenuated the increase in lung wet-to-dry weight ratio and myeloperoxidase activity, and reduced protein concentration, neutrophil counts and TNF-alpha levels in bronchoalveolar lavage. This effect was further pronounced when milrinone was repeatedly inhaled. In mice with acid-induced ALI, milrinoneattenuated hypoxemia and prevented the increase in lung myeloperoxidase activity. CONCLUSIONS: Inhalation of aerosolized milrinone may present a novel therapeutic strategy for the treatment of ALI.
Authors: André Y Denault; Yoan Lamarche; Pierre Couture; Francois Haddad; Jean Lambert; Jean-Claude Tardif; Louis P Perrault Journal: Semin Cardiothorac Vasc Anesth Date: 2006-12
Authors: John J Haddad; Stephen C Land; William O Tarnow-Mordi; Marek Zembala; Danuta Kowalczyk; Ryszard Lauterbach Journal: J Pharmacol Exp Ther Date: 2002-02 Impact factor: 4.030
Authors: R Schmidt; U Meier; M Yabut-Perez; D Walmrath; F Grimminger; W Seeger; A Günther Journal: Am J Respir Crit Care Med Date: 2001-01 Impact factor: 21.405
Authors: Yoan Lamarche; Louis P Perrault; Simon Maltais; Karine Tétreault; Jean Lambert; André Y Denault Journal: Eur J Cardiothorac Surg Date: 2007-04-02 Impact factor: 4.191
Authors: Gordon D Rubenfeld; Ellen Caldwell; Eve Peabody; Jim Weaver; Diane P Martin; Margaret Neff; Eric J Stern; Leonard D Hudson Journal: N Engl J Med Date: 2005-10-20 Impact factor: 91.245
Authors: Vanessa Zambelli; Giuseppe Di Grigoli; Margherita Scanziani; Silvia Valtorta; Maria Amigoni; Sara Belloli; Cristina Messa; Antonio Pesenti; Ferruccio Fazio; Giacomo Bellani; Rosa Maria Moresco Journal: Intensive Care Med Date: 2012-01-26 Impact factor: 17.440
Authors: Siegfried Breitling; Adrienn Krauszman; Richa Parihar; Thomas Walther; Mark K Friedberg; Wolfgang M Kuebler Journal: Pulm Circ Date: 2015-12 Impact factor: 3.017
Authors: Nils Neye; Fabian Enigk; Sruti Shiva; Helmut Habazettl; Nikolaus Plesnila; Hermann Kuppe; Mark T Gladwin; Wolfgang M Kuebler Journal: Intensive Care Med Date: 2012-06-01 Impact factor: 17.440
Authors: André Y Denault; Jean S Bussières; Ramiro Arellano; Barry Finegan; Paul Gavra; François Haddad; Anne Q N Nguyen; France Varin; Annik Fortier; Sylvie Levesque; Yanfen Shi; Mahsa Elmi-Sarabi; Jean-Claude Tardif; Louis P Perrault; Jean Lambert Journal: Can J Anaesth Date: 2016-07-28 Impact factor: 6.713
Authors: Martin Albert; Daniel Corsilli; David R Williamson; Marc Brosseau; Patrick Bellemare; Stéphane Delisle; Anne Qn Nguyen; France Varin Journal: World J Crit Care Med Date: 2017-02-04
Authors: Massimo Antonelli; Elie Azoulay; Marc Bonten; Jean Chastre; Giuseppe Citerio; Giorgio Conti; Daniel De Backer; François Lemaire; Herwig Gerlach; Goran Hedenstierna; Michael Joannidis; Duncan Macrae; Jordi Mancebo; Salvatore M Maggiore; Alexandre Mebazaa; Jean-Charles Preiser; Jerôme Pugin; Jan Wernerman; Haibo Zhang Journal: Intensive Care Med Date: 2010-01-28 Impact factor: 17.440