Literature DB >> 18971305

Influence of interleukin 1alpha (IL-1alpha), IL-4, and IL-6 polymorphisms on genetic susceptibility to chronic osteomyelitis.

Aspasia Tsezou1, Lazaros Poultsides, Fotini Kostopoulou, Elias Zintzaras, Maria Satra, Sofia Kitsiou-Tzeli, Konstantinos N Malizos.   

Abstract

The association between cytokine gene polymorphisms and chronic osteomyelitis was investigated in order to determine whether genetic variability in cytokine genes predisposes to osteomyelitis susceptibility. Significant genotypic and allelic associations were observed between interleukin 1alpha (IL-1alpha) -889-C/T, IL-4 -1098-G/T and -590-C/T, and IL-6 -174-G/C polymorphisms and osteomyelitis in the Greek population, pointing towards their potential involvement in osteomyelitis pathogenesis.

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Year:  2008        PMID： 18971305      PMCID： PMC2593176          DOI： 10.1128/CVI.00209-08

Source DB:  PubMed          Journal:  Clin Vaccine Immunol        ISSN： 1556-679X


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