| Literature DB >> 18967290 |
S Ravisankar1, M Vasudevan, M Gandhimathi, B Suresh.
Abstract
A simple, precise and rapid reversed-phase HPLC method was developed for the simultaneous estimation of acetaminophen, ibuprofen and chlorzoxazone in formulations. The method was carried out on a Kromasil(R) C(8) column using a mixture of 0.2% triethylamine:acetonitrile (adjusted to pH 3.2 using dilute orthophosphoric acid), and detection was carried out at 215 nm using ketoprofen as internal standard. All these drugs showed linearity in the range of 2-10 mug ml(-1), and limits of quantification was found to be 10, 50 and 20 ng ml(-1) for acetaminophen, ibuprofen and chlorzoxazone, respectively.Entities:
Year: 1998 PMID： 18967290 DOI： 10.1016/s0039-9140(98)00043-5
Source DB: PubMed Journal: Talanta ISSN： 0039-9140 Impact factor: 6.057