Literature DB >> 1896452

Molecular characterization of a region of DNA associated with mutations at the agouti locus in the mouse.

S J Bultman1, L B Russell, G A Gutierrez-Espeleta, R P Woychik.   

Abstract

Molecular characterization of a radiation-induced agouti (a)-locus mutation has resulted in the isolation of a segment of DNA that maps at or near the a locus on chromosome 2 in the mouse. This region of DNA is deleted in several radiation- or chemical-induced homozygous-lethal a-locus mutations and is associated with specific DNA structural alterations in two viable a-locus mutations. We propose that DNA probes from this region of chromosome 2 will be useful for ultimately characterizing the individual gene or genes associated with a-locus function.

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Year:  1991        PMID： 1896452      PMCID： PMC52446          DOI： 10.1073/pnas.88.18.8062

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  21 in total

1.  Allelic variation within the Emv-15 locus defines genomic sequences closely linked to the agouti locus on mouse chromosome 2.

Authors:  L D Siracusa; L B Russell; N A Jenkins; N G Copeland
Journal:  Genetics       Date:  1987-09       Impact factor: 4.562

2.  'Formins': proteins deduced from the alternative transcripts of the limb deformity gene.

Authors:  R P Woychik; R L Maas; R Zeller; T F Vogt; P Leder
Journal:  Nature       Date:  1990-08-30       Impact factor: 49.962

3.  The long-range restriction map surrounding the mouse agouti locus reveals a disparity between physical and genetic distances.

Authors:  G S Barsh; C J Epstein
Journal:  Genomics       Date:  1989-07       Impact factor: 5.736

4.  Molecular and genetic characterization of a radiation-induced structural rearrangement in mouse chromosome 2 causing mutations at the limb deformity and agouti loci.

Authors:  R P Woychik; W M Generoso; L B Russell; K T Cain; N L Cacheiro; S J Bultman; P B Selby; M E Dickinson; B L Hogan; J C Rutledge
Journal:  Proc Natl Acad Sci U S A       Date:  1990-04       Impact factor: 11.205

5.  Functional and structural analyses of mouse genomic regions screened by the morphological specific-locus test.

Authors:  L B Russell
Journal:  Mutat Res       Date:  1989-05       Impact factor: 2.433

6.  Double cos site vectors: simplified cosmid cloning.

Authors:  P F Bates; R A Swift
Journal:  Gene       Date:  1983-12       Impact factor: 3.688

7.  Ultrastructural observations of lethal yellow (Ay/Ay) mouse embryos.

Authors:  P G Calarco; R A Pedersen
Journal:  J Embryol Exp Morphol       Date:  1976-02

8.  Physical and genetic characterization of a 75-kilobase deletion associated with al, a recessive lethal allele at the mouse agouti locus.

Authors:  G S Barsh; C J Epstein
Journal:  Genetics       Date:  1989-04       Impact factor: 4.562

9.  Recombinant inbred strain and interspecific backcross analysis of molecular markers flanking the murine agouti coat color locus.

Authors:  L D Siracusa; A M Buchberg; N G Copeland; N A Jenkins
Journal:  Genetics       Date:  1989-07       Impact factor: 4.562

10.  The lethal yellow allele-associated provirus results in the production of chimeric viral-host RNAs.

Authors:  M Lovett; C J Epstein
Journal:  Proc Natl Acad Sci U S A       Date:  1987-05       Impact factor: 11.205
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  6 in total

1.  Molecular and phenotypic analysis of 25 recessive, homozygous-viable alleles at the mouse agouti locus.

Authors:  Rosalynn J Miltenberger; Kazumasa Wakamatsu; Shosuke Ito; Richard P Woychik; Liane B Russell; Edward J Michaud
Journal:  Genetics       Date:  2002-02       Impact factor: 4.562

2.  Comparison of the genetic effects of equimolar doses of ENU and MNU: while the chemicals differ dramatically in their mutagenicity in stem-cell spermatogonia, both elicit very high mutation rates in differentiating spermatogonia.

Authors:  Liane B Russell; Patricia R Hunsicker; William L Russell
Journal:  Mutat Res       Date:  2006-12-14       Impact factor: 2.433

3.  Unraveling the melanocyte.

Authors:  V J Hearing
Journal:  Am J Hum Genet       Date:  1993-01       Impact factor: 11.025

Review 4.  Biological insights through genomics: mouse to man.

Authors:  E M Rubin; G S Barsh
Journal:  J Clin Invest       Date:  1996-01-15       Impact factor: 14.808

5.  Molecular basis of the pleiotropic phenotype of mice carrying the hypervariable yellow (Ahvy) mutation at the agouti locus.

Authors:  A C Argeson; K K Nelson; L D Siracusa
Journal:  Genetics       Date:  1996-02       Impact factor: 4.562

6.  Agouti revisited: transcript quantification of the ASIP gene in bovine tissues related to protein expression and localization.

Authors:  Elke Albrecht; Katrin Komolka; Judith Kuzinski; Steffen Maak
Journal:  PLoS One       Date:  2012-04-17       Impact factor: 3.240
  6 in total

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