Literature DB >> 18957041

BeadArray-based solutions for enabling the promise of pharmacogenomics.

Jian-Bing Fan1, Sean Hu, William Craumer, David Barker.   

Abstract

A "one-size-fits-all" approach continues to characterize today's healthcare paradigm. But emergent rules, information, genomics tools, and economics are driving a fundamental and inevitable shift to a more personalized world of medicine. In this new world, the interests of insurers, regulators, suppliers, healthcare providers, and most important, patients, will have converged. The new goal will be the right treatment for the right individual at the right time. In this world, personalized medicine, through pharmacogenomics (PGx), will be the new healthcare paradigm. We will briefly examine healthcare trends and current opportunities for PGx development. We will then demonstrate how microarray technologies--among them bead-based approaches--have emerged as a key enabler for bringing home the promise of PGx.

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Year:  2005        PMID: 18957041     DOI: 10.2144/000112047

Source DB:  PubMed          Journal:  Biotechniques        ISSN: 0736-6205            Impact factor:   1.993


  2 in total

1.  Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot".

Authors:  Sharon E Johnatty; Jonathan Beesley; Xiaoqing Chen; Stuart Macgregor; David L Duffy; Amanda B Spurdle; Anna deFazio; Natalie Gava; Penelope M Webb; Mary Anne Rossing; Jennifer Anne Doherty; Marc T Goodman; Galina Lurie; Pamela J Thompson; Lynne R Wilkens; Roberta B Ness; Kirsten B Moysich; Jenny Chang-Claude; Shan Wang-Gohrke; Daniel W Cramer; Kathryn L Terry; Susan E Hankinson; Shelley S Tworoger; Montserrat Garcia-Closas; Hannah Yang; Jolanta Lissowska; Stephen J Chanock; Paul D Pharoah; Honglin Song; Alice S Whitemore; Celeste L Pearce; Daniel O Stram; Anna H Wu; Malcolm C Pike; Simon A Gayther; Susan J Ramus; Usha Menon; Aleksandra Gentry-Maharaj; Hoda Anton-Culver; Argyrios Ziogas; Estrid Hogdall; Susanne K Kjaer; Claus Hogdall; Andrew Berchuck; Joellen M Schildkraut; Edwin S Iversen; Patricia G Moorman; Catherine M Phelan; Thomas A Sellers; Julie M Cunningham; Robert A Vierkant; David N Rider; Ellen L Goode; Izhak Haviv; Georgia Chenevix-Trench
Journal:  PLoS Genet       Date:  2010-07-08       Impact factor: 5.917

2.  Meiotic Heterogeneity of Trivalent Structure and Interchromosomal Effect in Blastocysts With Robertsonian Translocations.

Authors:  Shuo Zhang; Caixia Lei; Junping Wu; Jing Zhou; Min Xiao; Saijuan Zhu; Yanping Xi; Jing Fu; Yijuan Sun; Congjian Xu; Xiaoxi Sun
Journal:  Front Genet       Date:  2021-02-16       Impact factor: 4.599

  2 in total

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