OBJECTIVE: Symptomatic fetal viral infection can affect placental and fetal development and may lead to non-immune hydrops or fetal death. All infections are not detectable by clinical history or ultrasound and a background positivity rate exists in asymptomatic patients. We investigated if intraamniotic presence of viral genome at the time of genetic amniocentesis in asypmtomatic patients affects perinatal outcome. STUDY DESIGN: Six-hundred and eighty-six pregnancies referred for second trimester genetic amniocentesis with a normal ultrasound and fetal karyotype had amniotic fluid multiplex polymerase chain reaction for adeno-, cytomegalo-, Ebstein-Barr-, entero- and parvovirus. Forty asymptomatic patients that were positive for viral genome were matched 2:1 with negative controls. Perinatal outcomes were compared between these groups. RESULTS: Pregnancy complications and perinatal outcomes were similar in the two groups. CONCLUSION: Asymptomatic fetal viral infection at the time of second trimester amniocentesis does not increase the risk for adverse perinatal outcome.
OBJECTIVE: Symptomatic fetal viral infection can affect placental and fetal development and may lead to non-immune hydrops or fetal death. All infections are not detectable by clinical history or ultrasound and a background positivity rate exists in asymptomatic patients. We investigated if intraamniotic presence of viral genome at the time of genetic amniocentesis in asypmtomatic patients affects perinatal outcome. STUDY DESIGN: Six-hundred and eighty-six pregnancies referred for second trimester genetic amniocentesis with a normal ultrasound and fetal karyotype had amniotic fluid multiplex polymerase chain reaction for adeno-, cytomegalo-, Ebstein-Barr-, entero- and parvovirus. Forty asymptomatic patients that were positive for viral genome were matched 2:1 with negative controls. Perinatal outcomes were compared between these groups. RESULTS:Pregnancy complications and perinatal outcomes were similar in the two groups. CONCLUSION: Asymptomatic fetal viral infection at the time of second trimester amniocentesis does not increase the risk for adverse perinatal outcome.
Authors: Chong Jai Kim; Roberto Romero; Juan Pedro Kusanovic; Wonsuk Yoo; Zhong Dong; Vanessa Topping; Francesca Gotsch; Bo Hyun Yoon; Je Geun Chi; Jung-Sun Kim Journal: Mod Pathol Date: 2010-03-26 Impact factor: 7.842
Authors: E Honkaniemi; G Talekar; W Huang; G Bogdanovic; E Forestier; U von Doblen; M Engvall; D A Ornelles; L R Gooding; B Gustafsson Journal: Br J Cancer Date: 2010-03-02 Impact factor: 7.640
Authors: Eunjung Jung; Roberto Romero; Bo Hyun Yoon; Kevin R Theis; Dereje W Gudicha; Adi L Tarca; Ramiro Diaz-Primera; Andrew D Winters; Nardhy Gomez-Lopez; Lami Yeo; Chaur-Dong Hsu Journal: J Perinat Med Date: 2021-07-07 Impact factor: 2.716