Literature DB >> 18956868

Cell-permeable esters of diazeniumdiolate-based nitric oxide prodrugs.

Harinath Chakrapani1, Anna E Maciag, Michael L Citro, Larry K Keefer, Joseph E Saavedra.   

Abstract

Although O(2)-(2,4-dinitrophenyl) derivatives of diazeniumdiolate-based nitric oxide (NO) prodrugs bearing a free carboxylic acid group were activated by glutathione to release NO, these compounds were poor sources of intracellular NO and showed diminished antiproliferative activity against human leukemia HL-60 cells. The carboxylic acid esters of these prodrugs, however, were found to be superior sources of intracellular NO and potent inhibitors of HL-60 cell proliferation.

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Year:  2008        PMID： 18956868      PMCID： PMC6939382          DOI： 10.1021/ol8020989

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  34 in total

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  4 in total

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