P F Grima1, R Chiavaroli, P Grima. 1. Operative Unit of Infectious Diseases, S. Caterina Novella's Hospital, Via Roma 1, 73013, Galatina, Lecce, Italy. pierfrancescogrima@yahoo.it
Abstract
PURPOSE: We performed a cross-sectional study of physical changes in HIV-infected adults to evaluate the role of ultrasonography for the diagnosis of lipodystrophy. MATERIALS AND METHODS: Sixty HIV-infected patients were recruited from 1 June to 31 December 2006. A total of 34 patients were included in the lipodystrophy group and 26 in no lipodystrophy group. Thickness of subcutaneous fat was measured twice with a high-frequency (15 MHz) transducer by transverse scans at four skin-based reference points: the periumbilical region, the brachial region, the crural region and the malar region. Visceral fat thickness was determined with a low-frequency (3.75 MHz) transducer at two skin reference points: perirenal fat diameter and visceral abdominal fat. RESULTS: Compared with HIV-infected patients without lipodystrophy, those with lipoatrophy or mixed lipodystrophy had thinner facial, arm and leg fat, whereas patients with lipodystrophy showed thicker intra-abdominal fat. The median of the ratio between intra-abdominal fat and subcutaneous fat and between perirenal fat diameter and body mass index in the lipodystrophy group was higher than in the no lipodystrophy group. The measurements of brachial, malar and crural fat were significantly lower in patients with lipodystrophy. CONCLUSIONS: We consider the ratio between visceral adipose tissue and subcutaneous adipose tissue and the thickness of malar fat to be the most useful ultrasonographic parameters for the early diagnosis of lipodystrophy in HIV-infected patients on highly active antiretroviral therapy.
PURPOSE: We performed a cross-sectional study of physical changes in HIV-infected adults to evaluate the role of ultrasonography for the diagnosis of lipodystrophy. MATERIALS AND METHODS: Sixty HIV-infectedpatients were recruited from 1 June to 31 December 2006. A total of 34 patients were included in the lipodystrophy group and 26 in no lipodystrophy group. Thickness of subcutaneous fat was measured twice with a high-frequency (15 MHz) transducer by transverse scans at four skin-based reference points: the periumbilical region, the brachial region, the crural region and the malar region. Visceral fat thickness was determined with a low-frequency (3.75 MHz) transducer at two skin reference points: perirenal fat diameter and visceral abdominal fat. RESULTS: Compared with HIV-infectedpatients without lipodystrophy, those with lipoatrophy or mixed lipodystrophy had thinner facial, arm and leg fat, whereas patients with lipodystrophy showed thicker intra-abdominal fat. The median of the ratio between intra-abdominal fat and subcutaneous fat and between perirenal fat diameter and body mass index in the lipodystrophy group was higher than in the no lipodystrophy group. The measurements of brachial, malar and crural fat were significantly lower in patients with lipodystrophy. CONCLUSIONS: We consider the ratio between visceral adipose tissue and subcutaneous adipose tissue and the thickness of malar fat to be the most useful ultrasonographic parameters for the early diagnosis of lipodystrophy in HIV-infectedpatients on highly active antiretroviral therapy.
Authors: Azucena Rodriguez-Guardado; Jose Antonio Maradona; Victor Asensi; Jose Antonio Cartón; Luis Casado Journal: J Acquir Immune Defic Syndr Date: 2003-03-01 Impact factor: 3.731
Authors: Víctor Asensi; Eustaquio Martín-Roces; José A Carton; Julio Collazos; José A Maradona; Angeles Alonso; Marifé Medina; Jesús M Aburto; Esteban Martínez; Carmen Rojo; Enrique Bustillo; Cristina Fernández; José M Arribas Journal: Clin Infect Dis Date: 2004-07-01 Impact factor: 9.079
Authors: Dianne Carey; Handan Wand; Allison Martin; Sharyn Rothwell; Sean Emery; David A Cooper; Andrew Carr Journal: AIDS Date: 2005-08-12 Impact factor: 4.177
Authors: Robert Burgoyne; Evan Collins; Cheryl Wagner; Susan Abbey; Mark Halman; Margaret Nur; Sharon Walmsley Journal: Qual Life Res Date: 2005-05 Impact factor: 4.147
Authors: Mark S Sulkowski; Shruti H Mehta; Michael Torbenson; Nezam H Afdhal; Lisa Mirel; Richard D Moore; David L Thomas Journal: AIDS Date: 2005-03-24 Impact factor: 4.177
Authors: K A Lichtenstein; D J Ward; A C Moorman; K M Delaney; B Young; F J Palella; P H Rhodes; K C Wood; S D Holmberg Journal: AIDS Date: 2001-07-27 Impact factor: 4.177
Authors: Shruti H Mehta; Richard D Moore; David L Thomas; Richard E Chaisson; Mark S Sulkowski Journal: J Acquir Immune Defic Syndr Date: 2003-08-15 Impact factor: 3.731