Angioma serpiginosum with sole involvement.

Angioma serpiginosum, which is characterized by multiple, minute, angiomatous puncta, is mainly located on the lower extremities of girls under the age of 16. Although any region of the body may be involved, lesions located on the palms and soles have never been reported. The lesions occur in groups, forming serpiginous patterns and rarely follow Blaschko's lines. Increased levels of estrogens have been proposed in the development of angioma serpiginosum. Here, we describe a 16-year-old girl with AS following the Blaschko's lines along the whole left lower extremity, also involving the left sole. Immunohistochemical studies showed the absence of estrogen and progesterone receptors within the involved blood vessels, indicating no role of hormonal stimuli in the initiation of this clinical picture.