| Literature DB >> 18955051 |
Keisuke Tachibana1, Naohiko Anzai, Chihiro Ueda, Tatsuya Katayama, Daisuke Yamasaki, Takayoshi Kirino, Rika Takahashi, Kenji Ishimoto, Hidenori Komori, Toshiya Tanaka, Takao Hamakubo, Yukihiko Ueda, Hiroyuki Arai, Juro Sakai, Tatsuhiko Kodama, Takefumi Doi.
Abstract
Although PDZK1 is a well-known adaptor protein, the mechanisms for its role in transcriptional regulation are largely unknown. The peroxisome proliferator-activated receptor alpha (PPARalpha) is a ligand-activated transcription factor that plays an important role in the regulation of lipid homeostasis. Previously, we established a tetracycline-regulated human cell line that can be induced to express PPARalpha and identified candidate target genes, one of which was PDZK1. In this study, we cloned and characterized the promoter region of the human pdzk1 gene and determined the PPAR response element. Finally, we demonstrate that endogenous PPARalpha regulates PDZK1 expression.Entities:
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Year: 2008 PMID： 18955051 DOI： 10.1016/j.febslet.2008.10.027
Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124