Literature DB >> 18954992

Efficient synthesis and biological evaluation of two modafinil analogues.

Carmela De Risi1, Luca Ferraro, Gian P Pollini, Sergio Tanganelli, Filippo Valente, Augusto C Veronese.   

Abstract

Non classical bioisosters of modafinil featuring interesting biological profile have been easily produced through replacement of the sulfoxide function with a carbonyl group and modification of the carboxylic acid amide functionality.

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Year:  2008        PMID： 18954992     DOI： 10.1016/j.bmc.2008.10.027

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  4 in total

1.  Structure-Activity Relationships at the Monoamine Transporters for a Novel Series of Modafinil (2-[(diphenylmethyl)sulfinyl]acetamide) Analogues.

Authors:  Jianjing Cao; Thomas E Prisinzano; Oluyomi M Okunola; Theresa Kopajtic; Matthew Shook; Jonathan L Katz; Amy Hauck Newman
Journal:  ACS Med Chem Lett       Date:  2010-10-10       Impact factor: 4.345

2.  Synthesis and psychobiological evaluation of modafinil analogs in mice.

Authors:  Arezou Lari; Isaac Karimi; Hadi Adibi; Alireza Aliabadi; Loghman Firoozpour; Alireza Foroumadi
Journal:  Daru       Date:  2013-12-19       Impact factor: 3.117

3.  Convenient synthesis and biological evaluation of modafinil derivatives: benzhydrylsulfanyl and benzhydrylsulfinyl [1,2,3]triazol-4-yl-methyl esters.

Authors:  Jae-Chul Jung; Yeonju Lee; Jee-Young Son; Eunyoung Lim; Mankil Jung; Seikwan Oh
Journal:  Molecules       Date:  2011-12-15       Impact factor: 4.411

4.  Simple synthesis of modafinil derivatives and their anti-inflammatory activity.

Authors:  Jae-Chul Jung; Yeonju Lee; Jee-Young Son; Eunyoung Lim; Mankil Jung; Seikwan Oh
Journal:  Molecules       Date:  2012-09-03       Impact factor: 4.411
  4 in total

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