| Literature DB >> 18954985 |
Linda M Bannwart1, David S Carter, Hai-Ying Cai, Jason C Choy, Robert Greenhouse, Saul Jaime-Figueroa, Pravin S Iyer, Clara J Lin, Eun Kyung Lee, Matthew C Lucas, Stephen M Lynch, Ann Marie Madera, Amy Moore, Kerem Ozboya, Lubica Raptova, Ralf Roetz, Ryan C Schoenfeld, Karin Ann Stein, Sandra Steiner, Marzia Villa, Robert J Weikert, Yansheng Zhai.
Abstract
A series of 3,3-disubstituted pyrrolidine monoamine triple reuptake inhibitors were discovered. Analogues with low nanomolar potency, good human in vitro microsomal stability and in vitro permeability, and low drug-drug interaction potential are described. One example showed in vivo anti-depressant-like effects in the mouse tail suspension assay with a minimum effective dose of 30 mg/kg i.p.Entities:
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Year: 2008 PMID： 18954985 DOI： 10.1016/j.bmcl.2008.10.025
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823