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Literature DB >> 18954554

Immunoglobulin expression and its biological significance in cancer cells.

Duosha Hu¹, Hui Zheng, Haidan Liu, Ming Li, Wei Ren, Wei Liao, Zhi Duan, Lili Li, Ya Cao.

Abstract

It is generally believed that the expression of a gene is restricted "within the right place and at the right time". This principle has long been considered applicable as well to the expression of immunoglobulin (Ig) lymphocytes of B cell lineage. However, increasing evidence has shown Ig "paradoxically" expressed in malignant tumors of epithelial origin. We reviewed the recent progress in the study of cancer-derived Ig, and also discussed its mechanisms and possible functions, trying to arouse interest and attention to those working in the field of immunology and oncology.

Entities: Disease

Mesh：

Substances：

Year: 2008 PMID： 18954554 PMCID： PMC4652786 DOI： 10.1038/cmi.2008.39

Source DB: PubMed Journal: Cell Mol Immunol ISSN： 1672-7681 Impact factor: 11.530

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Cited

23 in total

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Journal: J Virol Date: 2017-08-10 Impact factor: 5.103

2. AID expression increased by TNF-α is associated with class switch recombination of Igα gene in cancers.

Authors: Zhi Duan; Hui Zheng; Haidan Liu; Ming Li; Min Tang; Xinxian Weng; Wei Yi; Ann M Bode; Ya Cao
Journal: Cell Mol Immunol Date: 2015-04-06 Impact factor: 11.530

3. Heterogeneity of aberrant immunoglobulin expression in cancer cells.

Authors: Duosha Hu; Zhi Duan; Ming Li; Yiqun Jiang; Haidan Liu; Hui Zheng; Lili Li; Ann M Bode; Zigang Dong; Ya Cao
Journal: Cell Mol Immunol Date: 2011-08-22 Impact factor: 11.530

4. Oral benzo[a]pyrene-induced cancer: two distinct types in different target organs depend on the mouse Cyp1 genotype.

Authors: Zhanquan Shi; Nadine Dragin; Marian L Miller; Keith F Stringer; Elisabet Johansson; Jing Chen; Shigeyuki Uno; Frank J Gonzalez; Carlos A Rubio; Daniel W Nebert
Journal: Int J Cancer Date: 2010-11-15 Impact factor: 7.396

Review 5. Oral benzo[a]pyrene: understanding pharmacokinetics, detoxication, and consequences--Cyp1 knockout mouse lines as a paradigm.

Authors: Daniel W Nebert; Zhanquan Shi; Marina Gálvez-Peralta; Shigeyuki Uno; Nadine Dragin
Journal: Mol Pharmacol Date: 2013-06-12 Impact factor: 4.436

6. Activation of the Ig Iα1 promoter by the transcription factor Ets-1 triggers Ig Iα1-Cα1 germline transcription in epithelial cancer cells.

Authors: Zhi Duan; Hui Zheng; San Xu; Yiqun Jiang; Haidan Liu; Ming Li; Duosha Hu; Wei Li; Ann M Bode; Zigang Dong; Ya Cao
Journal: Cell Mol Immunol Date: 2013-11-04 Impact factor: 11.530

10. Overexpression of immunoglobulin G prompts cell proliferation and inhibits cell apoptosis in human urothelial carcinoma.

Authors: Pei-Yu Liang; Hao-Yong Li; Zhi-Yan Zhou; Ying-Xia Jin; Sheng-Xing Wang; Xiao-Hui Peng; Shan-Ji Ou
Journal: Tumour Biol Date: 2013-03-13