Literature DB >> 1895407

Recovery of infectious human immunodeficiency virus type 1 after fusion of defectively infected clones of U-937 cells.

F Boulerice1, X G Li, A Lvovich, M A Wainberg.   

Abstract

Polyethylene glycol was used to induce polykaryon formation among U-937 cell subclones carrying defective human immunodeficiency virus (HIV) type 1 proviral DNA. Fusion of cells which produced gp120-defective virions (UHC15.7) with cells unable to generate reverse transcriptase (RT) activity (UHC8 and UHC18) yielded polykaryons which made infectious viral progeny that showed normal protein profiles. Southern blot analysis of proviral DNA of cells infected with such fusion-derived virus revealed a restriction map identical to that of cells harboring infectious parental-type HIV type 1 (U-937/UHC1). These results suggest that repair mechanisms involving genetic recombination(s) play a role in the generation of infectious virus after fusion of cells which harbor defective HIV.

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Year:  1991        PMID： 1895407      PMCID： PMC249071     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  21 in total

1.  Genomic diversity of the acquired immune deficiency syndrome virus HTLV-III: different viruses exhibit greatest divergence in their envelope genes.

Authors:  B H Hahn; M A Gonda; G M Shaw; M Popovic; J A Hoxie; R C Gallo; F Wong-Staal
Journal:  Proc Natl Acad Sci U S A       Date:  1985-07       Impact factor: 11.205

2.  Low fidelity of cell-free DNA synthesis by reverse transcriptase of human immunodeficiency virus.

Authors:  Y Takeuchi; T Nagumo; H Hoshino
Journal:  J Virol       Date:  1988-10       Impact factor: 5.103

3.  Molecular characterization of a polymerase mutant human immunodeficiency virus.

Authors:  H E Gendelman; T S Theodore; R Willey; J McCoy; A Adachi; R J Mervis; S Venkatesan; M A Martin
Journal:  Virology       Date:  1987-10       Impact factor: 3.616

4.  HIV with reduced sensitivity to zidovudine (AZT) isolated during prolonged therapy.

Authors:  B A Larder; G Darby; D D Richman
Journal:  Science       Date:  1989-03-31       Impact factor: 47.728

5.  An inhibitor of the protease blocks maturation of human and simian immunodeficiency viruses and spread of infection.

Authors:  P Ashorn; T J McQuade; S Thaisrivongs; A G Tomasselli; W G Tarpley; B Moss
Journal:  Proc Natl Acad Sci U S A       Date:  1990-10       Impact factor: 11.205

6.  Generation of hybrid human immunodeficiency virus by homologous recombination.

Authors:  A Srinivasan; D York; R Jannoun-Nasr; S Kalyanaraman; D Swan; J Benson; C Bohan; P A Luciw; S Schnoll; R A Robinson
Journal:  Proc Natl Acad Sci U S A       Date:  1989-08       Impact factor: 11.205

7.  Human immunodeficiency virus isolates from asymptomatic homosexual men and from AIDS patients have distinct biologic and genetic properties.

Authors:  R Balachandran; P Thampatty; A Enrico; C Rinaldo; P Gupta
Journal:  Virology       Date:  1991-01       Impact factor: 3.616

8.  Expression of defective virus and cytokine genes in murine AIDS.

Authors:  S C Cheung; S K Chattopadhyay; H C Morse; P M Pitha
Journal:  J Virol       Date:  1991-02       Impact factor: 5.103

9.  Biologic features of HIV-1 that correlate with virulence in the host.

Authors:  C Cheng-Mayer; D Seto; M Tateno; J A Levy
Journal:  Science       Date:  1988-04-01       Impact factor: 47.728

10.  Role of human immunodeficiency virus type 1-specific protease in core protein maturation and viral infectivity.

Authors:  C Peng; B K Ho; T W Chang; N T Chang
Journal:  J Virol       Date:  1989-06       Impact factor: 5.103
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  1 in total

1.  Homologous interference resulting from the presence of defective particles of human immunodeficiency virus type 1.

Authors:  R Bernier; M Tremblay
Journal:  J Virol       Date:  1995-01       Impact factor: 5.103
  1 in total

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