| Literature DB >> 18953725 |
Olesya Nosareva1, Andrey Nesterov, Alexander Boldyrev, Olga Smirnova, Yurii Tumanov, Galina Kouzmitcheva, Sergey Tatkov.
Abstract
Experimental preparations based on a DNA vaccine encoding the ESAT-6 antigen of Mycobacterium tuberculosis have been obtained (KpONE6) and studied for immunogenic effects in the murine model. The core of the preparation contains DNA of the recombinant plasmid pONE6 encapsulated within a spermidine-polyglucin conjugate, thereby protecting the DNA vaccine from degradation. KpONE6 induces a proliferative T-cell immune response in mice upon intramuscular immunization.Entities:
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Year: 2008 PMID： 18953725 DOI： 10.1515/bc.2008.063
Source DB: PubMed Journal: Biol Chem ISSN： 1431-6730 Impact factor: 3.915