Literature DB >> 18953678

RGD-IL-24, a novel tumor-targeted fusion cytokine: expression, purification and functional evaluation.

Bin Xiao1, Wei Li, Jun Yang, Gang Guo, Xu-Hu Mao, Quan-Ming Zou.   

Abstract

Targeting drugs to tumor cells is a central challenge for improving existing cancer therapies. ACDCRGDCFCG peptide (RGD-4C) binds to alphavbeta3 integrin, which is selectively expressed in tumor blood vessels and on the surface of some tumor cells. Interleukin 24 (IL-24) is a novel cancer growth-suppressing and apoptosis-inducing cytokine. To enhance the antitumor effect, we coupled RGD-4C to the N-terminus of IL-24 and expressed RGD-IL-24 in Escherichia coli. Cell proliferation and adhesion experiments revealed that RGD-IL-24 specifically binds to MCF-7 cancer cells, and induces apoptosis of MCF-7 cancer cells. These studies support the use of the RGD-IL-24 protein in tumor-targeting therapy.

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Year:  2008        PMID： 18953678     DOI： 10.1007/s12033-008-9115-y

Source DB:  PubMed          Journal:  Mol Biotechnol        ISSN： 1073-6085            Impact factor:   2.695


  20 in total

1.  Solution structures and integrin binding activities of an RGD peptide with two isomers.

Authors:  N Assa-Munt; X Jia; P Laakkonen; E Ruoslahti
Journal:  Biochemistry       Date:  2001-02-27       Impact factor: 3.162

2.  A simplified system for constructing recombinant adenoviral vectors containing heterologous peptides in the HI loop of their fiber knob.

Authors:  H Mizuguchi; N Koizumi; T Hosono; N Utoguchi; Y Watanabe; M A Kay; T Hayakawa
Journal:  Gene Ther       Date:  2001-05       Impact factor: 5.250

3.  Enhancement of the antiangiogenic activity of interleukin-12 by peptide targeted delivery of the cytokine to alphavbeta3 integrin.

Authors:  Erin B Dickerson; Nasim Akhtar; Howard Steinberg; Zun-Yi Wang; Mary J Lindstrom; Marcia L Padilla; Robert Auerbach; Stuart C Helfand
Journal:  Mol Cancer Res       Date:  2004-12       Impact factor: 5.852

4.  The cancer growth suppressor gene mda-7 selectively induces apoptosis in human breast cancer cells and inhibits tumor growth in nude mice.

Authors:  Z Z Su; M T Madireddi; J J Lin; C S Young; S Kitada; J C Reed; N I Goldstein; P B Fisher
Journal:  Proc Natl Acad Sci U S A       Date:  1998-11-24       Impact factor: 11.205

5.  Mechanistic aspects of mda-7/IL-24 cancer cell selectivity analysed via a bacterial fusion protein.

Authors:  Moira Sauane; Rahul V Gopalkrishnan; Heng-Tong Choo; Pankaj Gupta; Irina V Lebedeva; Adly Yacoub; Paul Dent; Paul B Fisher
Journal:  Oncogene       Date:  2004-10-07       Impact factor: 9.867

Review 6.  mda-7/IL-24, a novel cancer selective apoptosis inducing cytokine gene: from the laboratory into the clinic.

Authors:  Paul B Fisher; Rahul V Gopalkrishnan; Sunil Chada; Rajagopal Ramesh; Elizabeth A Grimm; Myrna R Rosenfeld; David T Curiel; Paul Dent
Journal:  Cancer Biol Ther       Date:  2003 Jul-Aug       Impact factor: 4.742

7.  MDA-7 (interleukin-24) inhibits the proliferation of renal carcinoma cells and interacts with free radicals to promote cell death and loss of reproductive capacity.

Authors:  Adly Yacoub; Clint Mitchell; Jessica Brannon; Elizabeth Rosenberg; Liang Qiao; Robert McKinstry; W Marston Linehan; Zao-shong Su; Devanand Sarkar; Irina V Lebedeva; Kristoffer Valerie; Rahul V Gopalkrishnan; Steven Grant; Paul B Fisher; Paul Dent
Journal:  Mol Cancer Ther       Date:  2003-07       Impact factor: 6.261

8.  Melanoma differentiation-associated gene 7/interleukin (IL)-24 is a novel ligand that regulates angiogenesis via the IL-22 receptor.

Authors:  Rajagopal Ramesh; Abner M Mhashilkar; Fumihiro Tanaka; Yuji Saito; Cynthia D Branch; Kerry Sieger; John B Mumm; Alexis L Stewart; Amelie Boquoi; Laure Dumoutier; Elizabeth A Grimm; Jean-Christophe Renauld; Sergei Kotenko; Sunil Chada; Amelia Boquio
Journal:  Cancer Res       Date:  2003-08-15       Impact factor: 12.701

9.  Melanoma differentiation associated gene-7/interleukin-24 promotes tumor cell-specific apoptosis through both secretory and nonsecretory pathways.

Authors:  Moira Sauane; Irina V Lebedeva; Zao-zhong Su; Heng-tong Choo; Aaron Randolph; Kristoffer Valerie; Paul Dent; Rahul V Gopalkrishnan; Paul B Fisher
Journal:  Cancer Res       Date:  2004-05-01       Impact factor: 12.701

10.  Coupling tumor necrosis factor-alpha with alphaV integrin ligands improves its antineoplastic activity.

Authors:  Flavio Curnis; Anna Gasparri; Angelina Sacchi; Renato Longhi; Angelo Corti
Journal:  Cancer Res       Date:  2004-01-15       Impact factor: 12.701
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  2 in total

Review 1.  Recent insights into apoptosis and toxic autophagy: The roles of MDA-7/IL-24, a multidimensional anti-cancer therapeutic.

Authors:  Luni Emdad; Praveen Bhoopathi; Sarmistha Talukdar; Anjan K Pradhan; Devanand Sarkar; Xiang-Yang Wang; Swadesh K Das; Paul B Fisher
Journal:  Semin Cancer Biol       Date:  2019-07-26       Impact factor: 15.707

2.  Construction of expressing vectors including melanoma differentiation-associated gene-7 (mda-7) fused with the RGD sequences for better tumor targeting.

Authors:  Mahboobeh Khodadad; Seyed Younes Hosseini; Fatemeh Shenavar; Nasrollah Erfani; Samaneh Bina; Shahin Ahmadian; Mohammad-Reza Fattahi; Reza Hajhosseini
Journal:  Iran J Basic Med Sci       Date:  2015-08       Impact factor: 2.699
  2 in total

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