BACKGROUND: Patients with anorexia nervosa (AN) are at a high risk of renal failure. Chronic kidney disease (CKD) is often missed in these patients because the serum creatinine is a poor marker of kidney function. We studied the utility of cystatin C to detect renal failure in this population. METHOD: Twenty-seven AN patients were studied. Glomerular filtration rates (GFR) were measured with the chromium-51- ethylenediaminetetraacetate ((51)Cr-EDTA) method. We compared the ability of creatinine and cystatin C to detect stage 3 CKD (GFR below 60 ml/min) by ROC curve analysis. RESULTS: In this cohort, there is no correlation between GFR and serum creatinine, but there is a significant correlation between cystatin C and GFR. By ROC analysis, the cystatin C concentration is better than the serum creatinine concentration for the detection of stage 3 CKD (area under the curve of 0.86 vs. 0.61, p = 0.05). CONCLUSION: Plasma cystatin C is better than serum creatinine in detecting stage 3 CKD in patients with AN. Copyright 2008 S. Karger AG, Basel.
BACKGROUND:Patients with anorexia nervosa (AN) are at a high risk of renal failure. Chronic kidney disease (CKD) is often missed in these patients because the serum creatinine is a poor marker of kidney function. We studied the utility of cystatin C to detect renal failure in this population. METHOD: Twenty-seven AN patients were studied. Glomerular filtration rates (GFR) were measured with the chromium-51- ethylenediaminetetraacetate ((51)Cr-EDTA) method. We compared the ability of creatinine and cystatin C to detect stage 3 CKD (GFR below 60 ml/min) by ROC curve analysis. RESULTS: In this cohort, there is no correlation between GFR and serum creatinine, but there is a significant correlation between cystatin C and GFR. By ROC analysis, the cystatin C concentration is better than the serum creatinine concentration for the detection of stage 3 CKD (area under the curve of 0.86 vs. 0.61, p = 0.05). CONCLUSION: Plasma cystatin C is better than serum creatinine in detecting stage 3 CKD in patients with AN. Copyright 2008 S. Karger AG, Basel.
Authors: Alfonso Segarra; Judith de la Torre; Natalia Ramos; Augusto Quiroz; Maria Garjau; Irina Torres; M Antonia Azancot; Montserrat López; Ana Sobrado Journal: Clin J Am Soc Nephrol Date: 2011-08-18 Impact factor: 8.237
Authors: Pierre Delanaye; Etienne Cavalier; Jérôme Morel; Manolie Mehdi; Nicolas Maillard; Guillaume Claisse; Bernard Lambermont; Bernard E Dubois; Pierre Damas; Jean-Marie Krzesinski; Alexandre Lautrette; Christophe Mariat Journal: BMC Nephrol Date: 2014-01-13 Impact factor: 2.388