Literature DB >> 18953085

Gender and attention deficits in children diagnosed with a Fetal Alcohol Spectrum Disorder.

Lisa E Herman1, Michelle C Acosta, Pi-Nian Chang.   

Abstract

BACKGROUND: A portion of children are born with Fetal Alcohol Spectrum Disorders (FASD). Most present with significant difficulties in attention, with attention-deficit/hyperactivity disorder (ADHD) being the most common psychiatric co-morbidity.
OBJECTIVES: The current study will describe behavioral and executive functioning (EF) deficits in attention in a group of children with FASD. Effects of gender and ADHD diagnosis will be explored.
METHODS: Existing data from the University of Minnesota's Pediatric Psychology clinic was utilized. Of 191 children with FASD in the database, 36 children (ages 6-16) had complete scores on measures of behavioral and EF attention deficits. Multivariate Analyses of Variance (MANOVA) were used to examine the impact of gender and ADHD diagnosis on behavioral checklist scores and on a variety of EF measures.
RESULTS: FASD males were significantly more likely to be diagnosed with ADHD (68%) than FASD females (29%). No impact of gender or diagnosis was found for behavioral measures of attention, but an interaction of gender and diagnosis emerged for EF. Females with ADHD evidenced deficits in EF compared to females without ADHD. However, males with ADHD performed better on measures of EF than their non-ADHD counterparts.
CONCLUSION: An ADHD diagnosis in FASD children needs to be reconsidered, especially for males.

Entities:  

Mesh:

Year:  2008        PMID: 18953085

Source DB:  PubMed          Journal:  Can J Clin Pharmacol        ISSN: 1198-581X


  14 in total

1.  Ventromedian forebrain dysgenesis follows early prenatal ethanol exposure in mice.

Authors:  Elizabeth A Godin; Deborah B Dehart; Scott E Parnell; Shonagh K O'Leary-Moore; Kathleen K Sulik
Journal:  Neurotoxicol Teratol       Date:  2010-11-11       Impact factor: 3.763

2.  Moderate-level prenatal alcohol exposure enhances acoustic startle magnitude and disrupts prepulse inhibition in adult rhesus monkeys.

Authors:  Mary L Schneider; Julie A Larson; Craig W Rypstat; Leslie M Resch; Andrew Roberts; Colleen F Moore
Journal:  Alcohol Clin Exp Res       Date:  2013-06-13       Impact factor: 3.455

Review 3.  Epigenetic mechanisms in alcohol- and adversity-induced developmental origins of neurobehavioral functioning.

Authors:  K E Boschen; S M Keller; T L Roth; A Y Klintsova
Journal:  Neurotoxicol Teratol       Date:  2018-01-02       Impact factor: 3.763

4.  Strain-specific vulnerability to alcohol exposure in utero via hippocampal parent-of-origin expression of deiodinase-III.

Authors:  Laura J Sittig; Pradeep K Shukla; Laura B K Herzing; Eva E Redei
Journal:  FASEB J       Date:  2011-03-23       Impact factor: 5.191

5.  Moderate-level prenatal alcohol exposure induces sex differences in dopamine d1 receptor binding in adult rhesus monkeys.

Authors:  Alexander K Converse; Colleen F Moore; James E Holden; Elizabeth O Ahlers; Jeffrey M Moirano; Julie A Larson; Leslie M Resch; Onofre T DeJesus; Todd E Barnhart; Robert J Nickles; Dhanabalan Murali; Bradley T Christian; Mary L Schneider
Journal:  Alcohol Clin Exp Res       Date:  2014-12       Impact factor: 3.455

6.  Deletion of TLR-4 attenuates fetal alcohol exposure-induced gene expression and social interaction deficits.

Authors:  Pradeep K Shukla; Avtar S Meena; Rupa Rao; RadhaKrishna Rao
Journal:  Alcohol       Date:  2018-04-18       Impact factor: 2.405

7.  Postnatal binge-like alcohol exposure decreases dendritic complexity while increasing the density of mature spines in mPFC Layer II/III pyramidal neurons.

Authors:  Gillian F Hamilton; Lee T Whitcher; Anna Y Klintsova
Journal:  Synapse       Date:  2010-02       Impact factor: 2.562

8.  Correspondence of parent report and laboratory measures of inattention and hyperactivity in children with heavy prenatal alcohol exposure.

Authors:  Leila Glass; Diana M Graham; Benjamin N Deweese; Kenneth Lyons Jones; Edward P Riley; Sarah N Mattson
Journal:  Neurotoxicol Teratol       Date:  2014-02-07       Impact factor: 3.763

9.  Low-dose thyroxine attenuates autism-associated adverse effects of fetal alcohol in male offspring's social behavior and hippocampal gene expression.

Authors:  Elif Tunc-Ozcan; Timothy M Ullmann; Pradeep K Shukla; Eva E Redei
Journal:  Alcohol Clin Exp Res       Date:  2013-06-13       Impact factor: 3.455

Review 10.  The gestational foundation of sex differences in development and vulnerability.

Authors:  J A DiPietro; K M Voegtline
Journal:  Neuroscience       Date:  2015-07-29       Impact factor: 3.590

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