Literature DB >> 18952425

Activation and inhibition of leukotriene A4 hydrolase aminopeptidase activity by diphenyl ether and derivatives.

Xiaolu Jiang1, Lu Zhou, Dengguo Wei, Hu Meng, Ying Liu, Luhua Lai.   

Abstract

The synthesis and biological evaluation of a series of diphenyl ether derivatives were described. The compounds can either activate or inhibit the aminopeptidase activity of leukotriene A(4) hydrolase, while at the same time do not influence the hydrolase activity. Further enzyme kinetics and molecular modeling investigation on these novel chemical activators revealed their possible activation mechanism. These compounds can be used as probes to regulate the aminopeptidase activity of leukotriene A(4) hydrolase.

Entities:  

Mesh：

Substances：

Year:  2008        PMID： 18952425     DOI： 10.1016/j.bmcl.2008.10.044

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  8 in total

1.  Effect of the leukotriene A4 hydrolase aminopeptidase augmentor 4-methoxydiphenylmethane in a pre-clinical model of pulmonary emphysema.

Authors:  Eliseu O De Oliveira; Kan Wang; Hye-Sik Kong; Suhyon Kim; Matthew Miessau; Robert J Snelgrove; Y Michael Shim; Mikell Paige
Journal:  Bioorg Med Chem Lett       Date:  2011-09-20       Impact factor: 2.823

2.  Substrate-dependent modulation of the leukotriene A4 hydrolase aminopeptidase activity and effect in a murine model of acute lung inflammation.

Authors:  Kyung Hyeon Lee; Nadia Fazal Ali; Soo Hyeon Lee; Zhimin Zhang; Marie Burdick; Zachary J Beaulac; Greg Petruncio; Linxia Li; Jiangdong Xiang; Ezra M Chung; Kenneth W Foreman; Schroeder M Noble; Yun M Shim; Mikell Paige
Journal:  Sci Rep       Date:  2022-06-08       Impact factor: 4.996

3.  Role of leukotriene A4 hydrolase aminopeptidase in the pathogenesis of emphysema.

Authors:  Mikell Paige; Kan Wang; Marie Burdick; Sunhye Park; Josiah Cha; Erin Jeffery; Nicholas Sherman; Y Michael Shim
Journal:  J Immunol       Date:  2014-04-25       Impact factor: 5.422

Review 4.  The enzymology of human eicosanoid pathways: the lipoxygenase branches.

Authors:  Roger Gregory Biringer
Journal:  Mol Biol Rep       Date:  2020-08-03       Impact factor: 2.316

5.  Molecular dynamics simulation study and hybrid pharmacophore model development in human LTA4H inhibitor design.

Authors:  Sundarapandian Thangapandian; Shalini John; Mahreen Arooj; Keun Woo Lee
Journal:  PLoS One       Date:  2012-04-05       Impact factor: 3.240

6.  The development of novel LTA4H modulators to selectively target LTB4 generation.

Authors:  Caroline M Low; Samia Akthar; Dhiren F Patel; Stephan Löser; Chi-Tung Wong; Patricia L Jackson; J Edwin Blalock; Stephen A Hare; Clare M Lloyd; Robert J Snelgrove
Journal:  Sci Rep       Date:  2017-03-17       Impact factor: 4.379

7.  Feasibility and physiological relevance of designing highly potent aminopeptidase-sparing leukotriene A4 hydrolase inhibitors.

Authors:  Shin Numao; Franziska Hasler; Claire Laguerre; Honnappa Srinivas; Nathalie Wack; Petra Jäger; Andres Schmid; Arnaud Osmont; Patrik Röthlisberger; Jeremy Houguenade; Christian Bergsdorf; Janet Dawson; Nathalie Carte; Andreas Hofmann; Christian Markert; Liz Hardaker; Andreas Billich; Romain M Wolf; Carlos A Penno; Birgit Bollbuck; Wolfgang Miltz; Till A Röhn
Journal:  Sci Rep       Date:  2017-10-19       Impact factor: 4.379

8.  Activation of Glutathione Peroxidase 4 as a Novel Anti-inflammatory Strategy.

Authors:  Cong Li; Xiaobing Deng; Xiaowen Xie; Ying Liu; José Pedro Friedmann Angeli; Luhua Lai
Journal:  Front Pharmacol       Date:  2018-10-03       Impact factor: 5.810
  8 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.