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Literature DB >> 18951081

Methed-up FOXOs can't in-Akt-ivate.

Abstract

In this issue of Molecular Cell, Yamagata et al. (2008) identify a role for the protein methyltransferase, PRMT1, in Akt-dependent regulation of the FOXO1 transcription factor and demonstrate another level of control in this critical metabolic and cell survival signaling pathway.

Entities: Chemical Disease Gene Species

Mesh：

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Year: 2008 PMID： 18951081 PMCID： PMC2603568 DOI： 10.1016/j.molcel.2008.10.006

Source DB: PubMed Journal: Mol Cell ISSN： 1097-2765 Impact factor: 17.970

10 in total

1. Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor.

Authors: A Brunet; A Bonni; M J Zigmond; M Z Lin; P Juo; L S Hu; M J Anderson; K C Arden; J Blenis; M E Greenberg
Journal: Cell Date: 1999-03-19 Impact factor: 41.582

Review 2. Protein arginine methyltransferases: evolution and assessment of their pharmacological and therapeutic potential.

Authors: Christopher D Krause; Zhi-Hong Yang; Young-Sun Kim; Jin-Hyung Lee; Jeffry R Cook; Sidney Pestka
Journal: Pharmacol Ther Date: 2006-09-26 Impact factor: 12.310

Review 3. Dynamic FoxO transcription factors.

Authors: Haojie Huang; Donald J Tindall
Journal: J Cell Sci Date: 2007-08-01 Impact factor: 5.285

Review 4. FoxO transcription factors in the maintenance of cellular homeostasis during aging.

Authors: Dervis A M Salih; Anne Brunet
Journal: Curr Opin Cell Biol Date: 2008-04-03 Impact factor: 8.382

5. Lysophosphatidylcholine-induced elevation of asymmetric dimethylarginine level by the NADPH oxidase pathway in endothelial cells.

Authors: Su-Jie Jia; De-Jian Jiang; Chang-Ping Hu; Xiao-Hong Zhang; Han-Wu Deng; Yuan-Jian Li
Journal: Vascul Pharmacol Date: 2005-11-23 Impact factor: 5.773

6. Regulation of glucose-6-phosphatase gene expression by protein kinase Balpha and the forkhead transcription factor FKHR. Evidence for insulin response unit-dependent and -independent effects of insulin on promoter activity.

Authors: D Schmoll; K S Walker; D R Alessi; R Grempler; A Burchell; S Guo; R Walther; T G Unterman
Journal: J Biol Chem Date: 2000-11-17 Impact factor: 5.157

1 in total

1. Chronic inhibition of mammalian target of rapamycin by rapamycin modulates cognitive and non-cognitive components of behavior throughout lifespan in mice.

Authors: J Halloran; S A Hussong; R Burbank; N Podlutskaya; K E Fischer; L B Sloane; S N Austad; R Strong; A Richardson; M J Hart; V Galvan
Journal: Neuroscience Date: 2012-06-28 Impact factor: 3.590

1 in total

Methed-up FOXOs can't in-Akt-ivate.

1. Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor.

Review 2. Protein arginine methyltransferases: evolution and assessment of their pharmacological and therapeutic potential.

Review 3. Dynamic FoxO transcription factors.

Review 4. FoxO transcription factors in the maintenance of cellular homeostasis during aging.

5. Lysophosphatidylcholine-induced elevation of asymmetric dimethylarginine level by the NADPH oxidase pathway in endothelial cells.

6. Regulation of glucose-6-phosphatase gene expression by protein kinase Balpha and the forkhead transcription factor FKHR. Evidence for insulin response unit-dependent and -independent effects of insulin on promoter activity.

7. Impaired regulation of hepatic glucose production in mice lacking the forkhead transcription factor Foxo1 in liver.

8. Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress.

9. Arginine methylation of FOXO transcription factors inhibits their phosphorylation by Akt.

10. FOXO transcription factors directly activate bim gene expression and promote apoptosis in sympathetic neurons.

1. Chronic inhibition of mammalian target of rapamycin by rapamycin modulates cognitive and non-cognitive components of behavior throughout lifespan in mice.