BACKGROUND: Multiple transfusions are frequently complicated by alloimmunization. This retrospective study aims to determine whether alloimmunization could be accounted for by racial differences between donors and recipients. MATERIALS AND METHODS: The development of alloantibodies were determined in 68 multi-transfused patients (thalassaemia, n=38) and (sickle cell anemia, n=30). RESULTS: The overall frequency of alloantibody formation in our patients is 22.06%. Thirteen patients received blood from the same ethnic group (Arab) and none developed antibodies, while of 47 patients who received multi-ethnic blood, 10 developed alloantibodies. CONCLUSIONS: Alloantibodies formation can be reduced by limiting the transfusion of RBC, collected from donors of the same ethnic origin.
BACKGROUND: Multiple transfusions are frequently complicated by alloimmunization. This retrospective study aims to determine whether alloimmunization could be accounted for by racial differences between donors and recipients. MATERIALS AND METHODS: The development of alloantibodies were determined in 68 multi-transfused patients (thalassaemia, n=38) and (sickle cell anemia, n=30). RESULTS: The overall frequency of alloantibody formation in our patients is 22.06%. Thirteen patients received blood from the same ethnic group (Arab) and none developed antibodies, while of 47 patients who received multi-ethnic blood, 10 developed alloantibodies. CONCLUSIONS: Alloantibodies formation can be reduced by limiting the transfusion of RBC, collected from donors of the same ethnic origin.
Authors: Amal El-Beshlawy; Alshymaa Ahmed Salama; Mohamed Roshdy El-Masry; Noha M El Husseiny; Asmaa M Abdelhameed Journal: Sci Rep Date: 2020-12-03 Impact factor: 4.379