Literature DB >> 18950946

Decreased production of MCP-1 and MMP-2 by keloid-derived fibroblasts.

Fa-Lai Yeh1, Horng-Der Shen, Hsiao-Yun Tai.   

Abstract

Keloid tissue results from aberrant wound healing. The underlying mechanism responsible for keloid formation remains unclear. The aim of this study was to analyse the production of tissue inflammatory mediators by normal and keloid-derived human dermal fibroblasts cultured in vitro. Production of monocyte chemoattractant protein 1 (MCP-1), matrix metalloproteinase 2 (MMP-2) and tissue inhibitor of metalloproteinase 2 (TIMP-2), with and without the addition of interleukin-1beta, was determined by enzyme-linked immunosorbant assay. Our results showed that IL-1beta (10 ng/ml) stimulated a statistically significant increase in MCP-1 and MMP-2 production and decreased production of TIMP-2 by both normal and keloid-derived fibroblasts (Student's t-test, p<0.05), but to differing extents. This may contribute to factors leading to keloid formation.

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Year:  2008        PMID： 18950946     DOI： 10.1016/j.burns.2008.06.018

Source DB:  PubMed          Journal:  Burns        ISSN： 0305-4179            Impact factor:   2.744


  7 in total

Review 1.  The Role of Chemokines in Fibrotic Wound Healing.

Authors:  Jie Ding; Edward E Tredget
Journal:  Adv Wound Care (New Rochelle)       Date:  2015-11-01       Impact factor: 4.730

2.  siRNA knockdown of tissue inhibitor of metalloproteinase-1 in keloid fibroblasts leads to degradation of collagen type I.

Authors:  Masayo Aoki; Koichi Miyake; Rei Ogawa; Teruyuki Dohi; Satoshi Akaishi; Hiko Hyakusoku; Takashi Shimada
Journal:  J Invest Dermatol       Date:  2013-09-16       Impact factor: 8.551

3.  Scrotal cutaneous verruciform xanthoma with monocyte chemoattractant protein-1 immunohistochemical study: a case report.

Authors:  Chihiro Ito; Riko Kitazawac; Kenji Makita; Takafumi Watanabe; Akihiro Toda; Ryuma Haraguchi; Shinji Tanaka; Sohei Kitazawa
Journal:  J Med Case Rep       Date:  2012-08-31

Review 4.  High-mobility Group Box Protein-1, Matrix Metalloproteinases, and Vitamin D in Keloids and Hypertrophic Scars.

Authors:  Dylan E Lee; Ryan M Trowbridge; Nagi T Ayoub; Devendra K Agrawal
Journal:  Plast Reconstr Surg Glob Open       Date:  2015-07-08

5.  In Situ Cytokine Expression and Morphometric Evaluation of Total Collagen and Collagens Type I and Type III in Keloid Scars.

Authors:  Isabela Rios da Silva; Luciana Colombo Rodrigues da Cunha Tiveron; Marcos Vinicius da Silva; Alberto Borges Peixoto; Carla Aparecida Xavier Carneiro; M A Dos Reis; Pedro Carvalho Furtado; Bárbara Rocha Rodrigues; Virmondes Rodrigues; Denise Bertulucci Rocha Rodrigues
Journal:  Mediators Inflamm       Date:  2017-05-30       Impact factor: 4.711

6.  Heterogeneity of mast cells and expression of Annexin A1 protein in a second degree burn model with silver sulfadiazine treatment.

Authors:  Helena Ribeiro Souza; Lucas Ribeiro de Azevedo; Lucas Possebon; Sara de Souza Costa; Melina Mizusaki Iyomasa-Pilon; Sonia Maria Oliani; Ana Paula Girol
Journal:  PLoS One       Date:  2017-03-09       Impact factor: 3.240

Review 7.  The Keloid Disorder: Heterogeneity, Histopathology, Mechanisms and Models.

Authors:  Grace C Limandjaja; Frank B Niessen; Rik J Scheper; Susan Gibbs
Journal:  Front Cell Dev Biol       Date:  2020-05-26
  7 in total

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