OBJECTIVES: A polygenic model has been proposed in order to explain the genetic susceptibility to sporadic breast cancer. According to this model, common population variants would be responsible for low to modest effects on the risk of developing the disease. We have carried out a high-throughput SNP genotyping project in order to shed some light on the complex genetic aetiology of non-familial breast cancer. METHODS: Ninety-one genes have been selected because of their implications in several candidate cell pathways for breast cancer. A total of 640 SNPs in these genes were genotyped in a series of 450 consecutive cases and 448 controls from mainland Spain. Promising SNPs were then studied in an independent series of 294 cases and 299 controls from the Canary Islands. RESULTS: In the first case-control series we identified 25 SNPs with P-values below 0.05 (under a 1 df Chi-square test), five of them with P-values below 0.01 (best=0.0008). In the stage 2 Canary Islands series, odd ratios (OR) for two SNPs in HUS1 were in a consistent direction. CONCLUSIONS: SNPs located at the gene HUS1 are good candidates for further investigation in independent association studies and functional assays.
OBJECTIVES: A polygenic model has been proposed in order to explain the genetic susceptibility to sporadic breast cancer. According to this model, common population variants would be responsible for low to modest effects on the risk of developing the disease. We have carried out a high-throughput SNP genotyping project in order to shed some light on the complex genetic aetiology of non-familial breast cancer. METHODS: Ninety-one genes have been selected because of their implications in several candidate cell pathways for breast cancer. A total of 640 SNPs in these genes were genotyped in a series of 450 consecutive cases and 448 controls from mainland Spain. Promising SNPs were then studied in an independent series of 294 cases and 299 controls from the Canary Islands. RESULTS: In the first case-control series we identified 25 SNPs with P-values below 0.05 (under a 1 df Chi-square test), five of them with P-values below 0.01 (best=0.0008). In the stage 2 Canary Islands series, odd ratios (OR) for two SNPs in HUS1 were in a consistent direction. CONCLUSIONS: SNPs located at the gene HUS1 are good candidates for further investigation in independent association studies and functional assays.
Authors: Gila Neta; Alina V Brenner; Erich M Sturgis; Ruth M Pfeiffer; Amy A Hutchinson; Briseis Aschebrook-Kilfoy; Meredith Yeager; Li Xu; William Wheeler; Michael Abend; Elaine Ron; Margaret A Tucker; Stephen J Chanock; Alice J Sigurdson Journal: Carcinogenesis Date: 2011-06-03 Impact factor: 4.944
Authors: Eva Esteban Cardeñosa; Inmaculada de Juan Jiménez; Sarai Palanca Suela; Isabel Chirivella González; Angel Segura Huerta; Ana Santaballa Beltran; María Casals El Busto; Eva Barragán González; Oscar Fuster Lluch; José Bermúdez Edo; Pascual Bolufer Gilabert Journal: Fam Cancer Date: 2012-12 Impact factor: 2.375
Authors: Maya Ghoussaini; Olivia Fletcher; Kyriaki Michailidou; Clare Turnbull; Marjanka K Schmidt; Ed Dicks; Joe Dennis; Qin Wang; Manjeet K Humphreys; Craig Luccarini; Caroline Baynes; Don Conroy; Melanie Maranian; Shahana Ahmed; Kristy Driver; Nichola Johnson; Nicholas Orr; Isabel dos Santos Silva; Quinten Waisfisz; Hanne Meijers-Heijboer; Andre G Uitterlinden; Fernando Rivadeneira; Per Hall; Kamila Czene; Astrid Irwanto; Jianjun Liu; Heli Nevanlinna; Kristiina Aittomäki; Carl Blomqvist; Alfons Meindl; Rita K Schmutzler; Bertram Müller-Myhsok; Peter Lichtner; Jenny Chang-Claude; Rebecca Hein; Stefan Nickels; Dieter Flesch-Janys; Helen Tsimiklis; Enes Makalic; Daniel Schmidt; Minh Bui; John L Hopper; Carmel Apicella; Daniel J Park; Melissa Southey; David J Hunter; Stephen J Chanock; Annegien Broeks; Senno Verhoef; Frans B L Hogervorst; Peter A Fasching; Michael P Lux; Matthias W Beckmann; Arif B Ekici; Elinor Sawyer; Ian Tomlinson; Michael Kerin; Frederik Marme; Andreas Schneeweiss; Christof Sohn; Barbara Burwinkel; Pascal Guénel; Thérèse Truong; Emilie Cordina-Duverger; Florence Menegaux; Stig E Bojesen; Børge G Nordestgaard; Sune F Nielsen; Henrik Flyger; Roger L Milne; M Rosario Alonso; Anna González-Neira; Javier Benítez; Hoda Anton-Culver; Argyrios Ziogas; Leslie Bernstein; Christina Clarke Dur; Hermann Brenner; Heiko Müller; Volker Arndt; Christa Stegmaier; Christina Justenhoven; Hiltrud Brauch; Thomas Brüning; Shan Wang-Gohrke; Ursula Eilber; Thilo Dörk; Peter Schürmann; Michael Bremer; Peter Hillemanns; Natalia V Bogdanova; Natalia N Antonenkova; Yuri I Rogov; Johann H Karstens; Marina Bermisheva; Darya Prokofieva; Elza Khusnutdinova; Annika Lindblom; Sara Margolin; Arto Mannermaa; Vesa Kataja; Veli-Matti Kosma; Jaana M Hartikainen; Diether Lambrechts; Betul T Yesilyurt; Giuseppe Floris; Karin Leunen; Siranoush Manoukian; Bernardo Bonanni; Stefano Fortuzzi; Paolo Peterlongo; Fergus J Couch; Xianshu Wang; Kristen Stevens; Adam Lee; Graham G Giles; Laura Baglietto; Gianluca Severi; Catriona McLean; Grethe Grenaker Alnaes; Vessela Kristensen; Anne-Lise Børrensen-Dale; Esther M John; Alexander Miron; Robert Winqvist; Katri Pylkäs; Arja Jukkola-Vuorinen; Saila Kauppila; Irene L Andrulis; Gord Glendon; Anna Marie Mulligan; Peter Devilee; Christie J van Asperen; Rob A E M Tollenaar; Caroline Seynaeve; Jonine D Figueroa; Montserrat Garcia-Closas; Louise Brinton; Jolanta Lissowska; Maartje J Hooning; Antoinette Hollestelle; Rogier A Oldenburg; Ans M W van den Ouweland; Angela Cox; Malcolm W R Reed; Mitul Shah; Ania Jakubowska; Jan Lubinski; Katarzyna Jaworska; Katarzyna Durda; Michael Jones; Minouk Schoemaker; Alan Ashworth; Anthony Swerdlow; Jonathan Beesley; Xiaoqing Chen; Kenneth R Muir; Artitaya Lophatananon; Suthee Rattanamongkongul; Arkom Chaiwerawattana; Daehee Kang; Keun-Young Yoo; Dong-Young Noh; Chen-Yang Shen; Jyh-Cherng Yu; Pei-Ei Wu; Chia-Ni Hsiung; Annie Perkins; Ruth Swann; Louiza Velentzis; Diana M Eccles; Will J Tapper; Susan M Gerty; Nikki J Graham; Bruce A J Ponder; Georgia Chenevix-Trench; Paul D P Pharoah; Mark Lathrop; Alison M Dunning; Nazneen Rahman; Julian Peto; Douglas F Easton Journal: Nat Genet Date: 2012-01-22 Impact factor: 38.330
Authors: Jasmin Teresa Ney; Ingolf Juhasz-Boess; Frank Gruenhage; Stefan Graeber; Rainer Maria Bohle; Michael Pfreundschuh; Erich Franz Solomayer; Gunter Assmann Journal: BMC Cancer Date: 2013-01-31 Impact factor: 4.430