| Literature DB >> 18950591 |
Frank Leo van de Veerdonk1, Mihai G Netea, Trees J Jansen, Liesbeth Jacobs, Ineke Verschueren, Jos W M van der Meer, Bart Jan Kullberg.
Abstract
The role of Toll-like receptor-9 (TLR9) in the recognition of Candida albicans and anti-Candida host defense was investigated in a murine model of disseminated candidiasis and in human peripheral blood mononuclear cells (PBMC). Blocking TLR9 by a specific inhibitor of human TLR9 or stimulation of cells isolated from TLR9-deficient (TLR9-/-) mice resulted in a 20-30% reduction in cytokine production induced by C. albicans. However, this defect was not accompanied by differences in mortality and organ fungal growth between TLR9-/- and TLR9+/+ mice. In conclusion, TLR9 is a pathogen-recognition receptor for C. albicans, and TLR9 is involved in the induction of cytokines in response to C. albicans. However, the cytokine defect in TLR9-/- mice is compensated by alternative pathways, and the TLR9-dependent pathway seems to be redundant in the disseminated candidiasis model in mice.Entities:
Mesh：
Substances：
Year: 2008 PMID： 18950591 DOI： 10.1016/j.imbio.2008.05.002
Source DB: PubMed Journal: Immunobiology ISSN： 0171-2985 Impact factor: 3.144