Matthew R Allen1. 1. Indiana University School of Medicine, Department of Anatomy & Cell Biology, 635 Barnhill Drive, MS-5035, IN 46202, Indianapolis, USA. matallen@iupui.edu
Abstract
BACKGROUND: Bisphosphonates (BPs), the gold-standard pharmacological treatment for osteoporosis, are unique in that they become physically bound to the bone matrix and therefore accumulate over time. This skeletal accumulation has important physiological implications that are not completely understood. OBJECTIVE: To review concepts related to the biological effects of BP accumulation in the skeleton. METHODS: Articles concerning skeletal accumulation of BP treatment were identified. RESULTS/ CONCLUSIONS: Skeletal accumulation of BP, dictated by both chemical and biological factors, is dose-dependent, differs among skeletal sites and likely differs among the various BPs. Bisphosphonate embedded within the skeletal matrix has lasting biological effects, the results of which have both positive and negative implications for bone remodeling. As alternative anti-remodeling agents gain approval for treatment of osteoporosis, the property of skeletal accumulation will likely be unique to BPs and therefore may be the property that determines the future use of this drug class.
BACKGROUND:Bisphosphonates (BPs), the gold-standard pharmacological treatment for osteoporosis, are unique in that they become physically bound to the bone matrix and therefore accumulate over time. This skeletal accumulation has important physiological implications that are not completely understood. OBJECTIVE: To review concepts related to the biological effects of BP accumulation in the skeleton. METHODS: Articles concerning skeletal accumulation of BP treatment were identified. RESULTS/ CONCLUSIONS: Skeletal accumulation of BP, dictated by both chemical and biological factors, is dose-dependent, differs among skeletal sites and likely differs among the various BPs. Bisphosphonate embedded within the skeletal matrix has lasting biological effects, the results of which have both positive and negative implications for bone remodeling. As alternative anti-remodeling agents gain approval for treatment of osteoporosis, the property of skeletal accumulation will likely be unique to BPs and therefore may be the property that determines the future use of this drug class.
Authors: Cory N Meixner; Mohammad W Aref; Aryaman Gupta; Erin M B McNerny; Drew Brown; Joseph M Wallace; Matthew R Allen Journal: Calcif Tissue Int Date: 2017-02-28 Impact factor: 4.333
Authors: Brianne S Raccor; Jianxun Sun; Ross F Lawrence; Lei Li; Hai Zhang; Martha J Somerman; Rheem A Totah Journal: J Chromatogr B Analyt Technol Biomed Life Sci Date: 2013-07-27 Impact factor: 3.205
Authors: Henrik Holtmann; Julian Lommen; Norbert R Kübler; Christoph Sproll; Majeed Rana; Patrick Karschuck; Rita Depprich Journal: J Int Med Res Date: 2018-08-09 Impact factor: 1.671