Nicolas Danchin1, Eric Durand, Didier Blanchard. 1. Hôpital Européen Georges Pompidou, Assistance Publique des Hôpitaux de Paris and Université Paris 5 René Descartes, Paris, France. nicolas.danchin@egp.aphp.fr
Abstract
AIMS: To review existing evidence on the role of pre-hospital fibrinolysis in patients with ST-elevation myocardial infarction (MI). METHODS AND RESULTS: Overview of current guidelines and data from trials and registries on the best perfusion approach for acute MI with ST-elevation. Despite advances in the treatment of ST-elevation MI, the mortality rate before any therapy is administered is high, with half of all fatalities occurring within 2 h of symptom onset. Current treatment options, including the timely use of pre-hospital fibrinolysis, have reduced the overall 1 month mortality. Mortality can be further improved when patient characteristics, risk factors and time delays to treatment are considered. CONCLUSION: Time factors are essential in the success of fibrinolysis, and subsequent coronary intervention seems beneficial.
AIMS: To review existing evidence on the role of pre-hospital fibrinolysis in patients with ST-elevation myocardial infarction (MI). METHODS AND RESULTS: Overview of current guidelines and data from trials and registries on the best perfusion approach for acute MI with ST-elevation. Despite advances in the treatment of ST-elevation MI, the mortality rate before any therapy is administered is high, with half of all fatalities occurring within 2 h of symptom onset. Current treatment options, including the timely use of pre-hospital fibrinolysis, have reduced the overall 1 month mortality. Mortality can be further improved when patient characteristics, risk factors and time delays to treatment are considered. CONCLUSION: Time factors are essential in the success of fibrinolysis, and subsequent coronary intervention seems beneficial.
Authors: Wojciech J Zimoch; Michał Kosowski; Brunon Tomasiewicz; Anna Langner; Piotr Kubler; Ewa A Jankowska; Krzysztof Reczuch Journal: Postepy Kardiol Interwencyjnej Date: 2015-09-28 Impact factor: 1.426