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Literature DB >> 18948255

Understanding the association of apolipoprotein E4 with Alzheimer disease: clues from its structure.

Abstract

Despite intense interest, the molecular mechanisms underlying the association of apoE4 with Alzheimer disease are not clear. Because the function (or dysfunction) of a protein is based on its structure, this review focuses on the effects of the structural differences among the isoforms on neurodegeneration. Understanding how apoE4 structure impacts neurodegeneration is likely to provide mechanistic insight as well as potential therapeutic approaches to blunt or reduce its effects.

Entities: Disease Gene

Mesh：

Substances：

Year: 2008 PMID： 18948255 PMCID： PMC2649104 DOI： 10.1074/jbc.R800009200

Source DB: PubMed Journal: J Biol Chem ISSN： 0021-9258 Impact factor: 5.157

42 in total

1. Amyloid fibrils from muscle myoglobin.

Authors: M Fändrich; M A Fletcher; C M Dobson
Journal: Nature Date: 2001-03-08 Impact factor: 49.962

2. Apolipoprotein E4 domain interaction occurs in living neuronal cells as determined by fluorescence resonance energy transfer.

Authors: Qin Xu; Walter J Brecht; Karl H Weisgraber; Robert W Mahley; Yadong Huang
Journal: J Biol Chem Date: 2004-03-30 Impact factor: 5.157

3. Apolipoprotein E4 potentiates amyloid beta peptide-induced lysosomal leakage and apoptosis in neuronal cells.

Authors: Zhong-Sheng Ji; R Dennis Miranda; Yvonne M Newhouse; Karl H Weisgraber; Yadong Huang; Robert W Mahley
Journal: J Biol Chem Date: 2002-03-23 Impact factor: 5.157

4. Introduction of human apolipoprotein E4 "domain interaction" into mouse apolipoprotein E.

Authors: R L Raffai; L M Dong; R V Farese; K H Weisgraber
Journal: Proc Natl Acad Sci U S A Date: 2001-09-11 Impact factor: 11.205

5. Apolipoprotein E isoform-dependent amyloid deposition and neuritic degeneration in a mouse model of Alzheimer's disease.

Authors: D M Holtzman; K R Bales; T Tenkova; A M Fagan; M Parsadanian; L J Sartorius; B Mackey; J Olney; D McKeel; D Wozniak; S M Paul
Journal: Proc Natl Acad Sci U S A Date: 2000-03-14 Impact factor: 11.205

6. Carboxyl-terminal-truncated apolipoprotein E4 causes Alzheimer's disease-like neurodegeneration and behavioral deficits in transgenic mice.

Authors: Faith M Harris; Walter J Brecht; Qin Xu; Ina Tesseur; Lisa Kekonius; Tony Wyss-Coray; Jo Dee Fish; Eliezer Masliah; Paul C Hopkins; Kimberly Scearce-Levie; Karl H Weisgraber; Lennart Mucke; Robert W Mahley; Yadong Huang
Journal: Proc Natl Acad Sci U S A Date: 2003-08-25 Impact factor: 11.205

7. Neuron-specific apolipoprotein e4 proteolysis is associated with increased tau phosphorylation in brains of transgenic mice.

Authors: Walter J Brecht; Faith M Harris; Shengjun Chang; Ina Tesseur; Gui-Qiu Yu; Qin Xu; Jo Dee Fish; Tony Wyss-Coray; Manuel Buttini; Lennart Mucke; Robert W Mahley; Yadong Huang
Journal: J Neurosci Date: 2004-03-10 Impact factor: 6.167

Review 8. Apolipoprotein E: diversity of cellular origins, structural and biophysical properties, and effects in Alzheimer's disease.

Authors: Yadong Huang; Karl H Weisgraber; Lennart Mucke; Robert W Mahley
Journal: J Mol Neurosci Date: 2004 Impact factor: 3.444

9. Apolipoprotein E4 domain interaction: synaptic and cognitive deficits in mice.

Authors: Ning Zhong; Kimberly Scearce-Levie; Gayathri Ramaswamy; Karl H Weisgraber
Journal: Alzheimers Dement Date: 2008-05 Impact factor: 21.566

10. Apolipoprotein E4 forms a molten globule. A potential basis for its association with disease.

Authors: Julie A Morrow; Danny M Hatters; Bin Lu; Peter Hochtl; Keith A Oberg; Bernhard Rupp; Karl H Weisgraber
Journal: J Biol Chem Date: 2002-10-21 Impact factor: 5.157

52 in total

1. To Keto or Not to Keto? A Systematic Review of Randomized Controlled Trials Assessing the Effects of Ketogenic Therapy on Alzheimer Disease.

Authors: Maria G Grammatikopoulou; Dimitrios G Goulis; Konstantinos Gkiouras; Xenophon Theodoridis; Kalliopi K Gkouskou; Athanasios Evangeliou; Efthimis Dardiotis; Dimitrios P Bogdanos
Journal: Adv Nutr Date: 2020-11-16 Impact factor: 8.701

Understanding the association of apolipoprotein E4 with Alzheimer disease: clues from its structure.

1. Amyloid fibrils from muscle myoglobin.

2. Apolipoprotein E4 domain interaction occurs in living neuronal cells as determined by fluorescence resonance energy transfer.

3. Apolipoprotein E4 potentiates amyloid beta peptide-induced lysosomal leakage and apoptosis in neuronal cells.

4. Introduction of human apolipoprotein E4 "domain interaction" into mouse apolipoprotein E.

5. Apolipoprotein E isoform-dependent amyloid deposition and neuritic degeneration in a mouse model of Alzheimer's disease.

6. Carboxyl-terminal-truncated apolipoprotein E4 causes Alzheimer's disease-like neurodegeneration and behavioral deficits in transgenic mice.

7. Neuron-specific apolipoprotein e4 proteolysis is associated with increased tau phosphorylation in brains of transgenic mice.

Review 8. Apolipoprotein E: diversity of cellular origins, structural and biophysical properties, and effects in Alzheimer's disease.

9. Apolipoprotein E4 domain interaction: synaptic and cognitive deficits in mice.

10. Apolipoprotein E4 forms a molten globule. A potential basis for its association with disease.

1. To Keto or Not to Keto? A Systematic Review of Randomized Controlled Trials Assessing the Effects of Ketogenic Therapy on Alzheimer Disease.

Review 2. Alzheimer mechanisms and therapeutic strategies.

Review 3. Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy.

Review 4. Cholesterol as a causative factor in Alzheimer's disease: a debatable hypothesis.

Review 5. The helix bundle: a reversible lipid binding motif.

6. APOE genotype-dependent modulation of astrocyte chemokine CCL3 production.

7. Full-length apolipoprotein E protects against the neurotoxicity of an apoE-related peptide.

8. Apolipoprotein E4 domain interaction induces endoplasmic reticulum stress and impairs astrocyte function.

Review 9. Apolipoprotein E, gender, and Alzheimer's disease: an overlooked, but potent and promising interaction.

Review 10. APOE and neuroenergetics: an emerging paradigm in Alzheimer's disease.