| Literature DB >> 18947997 |
Gloria A Breault1, Janelle Comita-Prevoir, Charles J Eyermann, Bolin Geng, Randy Petrichko, Peter Doig, Elise Gorseth, Brian Noonan.
Abstract
A successful scaffold-hopping approach gave a novel series of inhibitors of bacterial glutamate racemase (MurI). Early SAR studies of the 8-benzyl pteridine-6,7-diones led to compounds with micromolar enzyme potency and antibacterial activity.Entities:
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Year: 2008 PMID： 18947997 DOI： 10.1016/j.bmcl.2008.10.022
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823