| Literature DB >> 18947298 |
Danil V Makarov1, Stacy Loeb, Robert H Getzenberg, Alan W Partin.
Abstract
The development of biomarkers for prostate cancer screening, detection, and prognostication has revolutionized the management of this disease. Prostate-specific antigen (PSA) is a useful, though not specific, biomarker for detecting prostate cancer. We review the literature on prostate cancer biomarkers, including serum markers (PAP, tPSA, fPSA, proPSA, PSAD, PSAV, PSADT, EPCA, and EPCA-2), tissue markers (AMACR, methylated GSTP1, and the TMPRSS2-ETS gene rearrangement), and a urine marker (DD3PCA3/UPM-3). Future research should focus on validation of already existing biomarkers and the discovery of new markers to identify men with aggressive prostate cancer.Entities:
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Year: 2009 PMID: 18947298 DOI: 10.1146/annurev.med.60.042307.110714
Source DB: PubMed Journal: Annu Rev Med ISSN: 0066-4219 Impact factor: 13.739